Which type of research study is most appropriate to determine if premedication with diphenhydramine is more effective than acetaminophen to reduce the incidence of aseptic meningitis after intravenous globulin infusion?

A) Randomized trial
B) Qualitative study
C) Historical review
D) Descriptive report

Premedication

The administration of medication before a medical procedure or surgery to reduce anxiety, pain, or the risk of infection.

Diphenhydramine

An antihistamine medication used to relieve symptoms of allergy, hay fever, and the common cold, as well as for inducing sleep.

Aseptic Meningitis

A form of meningitis characterized by inflammation of the protective membranes covering the brain and spinal cord not caused by bacterial infection and typically less severe.