If A 1 represents an allele at one locus and B 1 represents an allele at another locus, which equation represents linkage disequilibrium?A) P A 1 B 1 = P A 1 ∗ P B 1 P _ { A _ { 1 } B _ { 1 } } = P _ { A _ { 1 } } * P _ { B _ { 1 } } P A 1 B 1 = P A 1 ∗ P B 1 B) P A 1 B 1 ≠ P A 1 ∗ P B 1 P _ { A _ { 1 } B _ { 1 } }
eq P _ { A _ { 1 } } * P _ { B _ { 1 } } P A 1 B 1  = P A 1 ∗ P B 1 C) D A 1 B 1 ≠ P A 1 ∗ P B 1 D _ { A _ { 1 } B _ { 1 } }
eq P _ { A _ { 1 } } * P _ { B _ { 1 } } D A 1 B 1  = P A 1 ∗ P B 1 D) D A 1 B 1 = P A 1 B 1 − P A 1 ∗ P B 1 D _ { A _ { 1 } B _ { 1 } } = P _ { A _ { 1 } B _ { 1 } } - P _ { A _ { 1 } } * P _ { B _ { 1 } } D A 1 B 1 = P A 1 B 1 − P A 1 ∗ P B 1

Question

If A 1  represents an allele at one locus and B 1  represents an allele at another locus, which equation represents linkage disequilibrium?A)    P A 1 B 1 = P A 1 ∗ P B 1 P _ { A _ { 1 } B _ { 1 } } = P _ { A _ { 1 } } * P _ { B _ { 1 } } P A 1 ​ B 1 ​ ​ = P A 1 ​ ​ ∗ P B 1 ​ ​ B)    P A 1 B 1 ≠ P A 1 ∗ P B 1 P _ { A _ { 1 } B _ { 1 } } 
eq P _ { A _ { 1 } } * P _ { B _ { 1 } } P A 1 ​ B 1 ​ ​  = P A 1 ​ ​ ∗ P B 1 ​ ​ C)    D A 1 B 1 ≠ P A 1 ∗ P B 1 D _ { A _ { 1 } B _ { 1 } } 
eq P _ { A _ { 1 } } * P _ { B _ { 1 } } D A 1 ​ B 1 ​ ​  = P A 1 ​ ​ ∗ P B 1 ​ ​ D)    D A 1 B 1 = P A 1 B 1 − P A 1 ∗ P B 1 D _ { A _ { 1 } B _ { 1 } } = P _ { A _ { 1 } B _ { 1 } } - P _ { A _ { 1 } } * P _ { B _ { 1 } } D A 1 ​ B 1 ​ ​ = P A 1 ​ B 1 ​ ​ − P A 1 ​ ​ ∗ P B 1 ​ ​

Herminia Gutierrez Vizcarra · Accepted Answer

Final Answer : B, Explanation :   Linkage disequilibrium is a non-random association of alleles at two or more loci. It is measured by the difference between the observed frequency of a particular haplotype and the expected frequency of that haplotype if the alleles were segregating independently. The equation that represents linkage disequilibrium is:  D A 1 B 1 ≠ P A 1 ∗ P B 1 D _ { A _ { 1 } B _ { 1 } } 
eq P _ { A _ { 1 } } * P _ { B _ { 1 } } D A 1 ​ B 1 ​ ​  = P A 1 ​ ​ ∗ P B 1 ​ ​

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