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Which statement is TRUE concerning the chloride-bicarbonate exchanger?


A) This transporter is electrogenic.
B) The exchanger is a passive antiporter.
C) This protein is involved in carbon dioxide transport in the blood stream.
D) The exchanger is a passive antiporter, and this protein is involved in carbon dioxide transport in the blood stream.
E) This transporter is electrogenic, and the exchanger is a passive antiporter.

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Which transporter will move lipids from the cytosolic leaflet to the outer leaflet of a plasma membrane?


A) a flippase
B) a floppase
C) a scramblase
D) both a flippase and a floppase
E) both a floppase and a scramblase

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Which statement about the composition of membranes is TRUE?


A) All biological membranes contain cholesterol.
B) Free fatty acids are major components of all membranes.
C) The inner and outer membranes of mitochondria have different protein compositions.
D) The lipid composition of all membranes of eukaryotic cells is essentially the same.
E) The lipid:protein ratio varies from about 1:4 to 4:1.

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Which statement is generally TRUE of integral membrane proteins?


A) The secondary structure in the transmembrane region consists solely of α\alpha helices or β\beta sheets.
B) The domains that protrude on the cytoplasmic face of the plasma membrane nearly always have covalently attached oligosaccharides.
C) They are unusually susceptible to degradation by trypsin.
D) They can be removed from the membrane with high salt or mild denaturing agents.
E) They undergo constant rotational motion that moves a given domain from the outer face of a membrane to the inner face and then back to the outer.

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A plant breeder has developed a new frost-resistant variety of tomato that contains higher levels of unsaturated fatty acids in membrane lipids than those found in standard tomato varieties. However, when temperatures climb above 95 °F, this frost-resistant variety dies, whereas the standard variety continues to grow. Provide a likely explanation of the biochemical basis of increased tolerance to cold and increased susceptibility to heat of this new tomato variety.

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The likely explanation for the biochemic...

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Integrins are:


A) membrane proteins that are involved in ion transport.
B) membrane proteins that are involved in sugar transport.
C) membrane proteins that mediate cell adhesion.
D) proteins of the extracellular matrix that bind to cell surface proteins.
E) proteins that are found at the membrane-cytoplasm interface.

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Which process does NOT require a protein facilitator?


A) simple diffusion
B) ionophore-mediated diffusion
C) a primary active uniport
D) a passive antiporter
E) both simple diffusion and ionophore-mediated diffusion

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(a) What kinds of forces or bonds anchor an integral membrane protein in a biological membrane? (b) What forces hold a peripheral membrane protein to the membrane? (c) What might one do to solubilize each of the two types of membrane proteins?

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(a) Integral membrane proteins are ancho...

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Which enzymes are NOT involved in moving phospholipids from one leaflet to another?


A) flippases that move phosphatidylethanolamine and phosphatidylserine
B) floppases that move phospholipids from the cytosolic leaflet to the extracellular leaflet
C) flip-floppases that allow phospholipids to move back and forth between the inner and outer leaflets
D) scramblases that allow phospholipids to move down their concentration gradient
E) phosphatidylinositol transfer proteins that play a role in lipid signaling

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Which structure describes an integral membrane protein containing a β\beta barrel?


A) maltoporin
B) aquaporin
C) E. coli OmpF
D) both maltoporin and E. coli OmpF
E) both maltoporin and aquaporin

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Describe two different ways a plant can adjust the components of its cell membranes to keep them as fluid as possible on a cold winter morning.

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One way a plant can adjust the component...

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Which transporter will move lipids from the outer leaflet to the cytosolic leaflet of a plasma membrane?


A) a flippase
B) a floppase
C) a scramblase
D) both a flippase and a floppase
E) both a flippase and a scramblase

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Which statement is NOT true about the chloride-bicarbonate exchanger (AE) ?


A) The AE protein increases the rate of bicarbonate transport across the membrane.
B) The AE protein uses ATP as an energy source to drive bicarbonate transport.
C) The AE protein transports chloride ions across the membrane.
D) The AE protein is classified as an anti-porter.
E) The AE protein spans the membrane at least 12 times.

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Describe a hydropathy plot for a hypothetical integral membrane protein with 3 transmembrane segments and containing 190 amino acids.

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A hydropathy plot is a graph that shows ...

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Which statement is TRUE for passive transport across a biological membrane?


A) Passive transport is driven by a solute electrochemical gradient.
B) Passive transport is driven by ATP.
C) Passive transport is irreversible.
D) Passive transport is driven by both a solute electrochemical gradient ATP.
E) Passive transport is driven by a solute electrochemical gradient and is irreversible.

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An integral membrane protein can be extracted with:


A) a buffer of alkaline or acid pH.
B) a chelating agent that removes divalent cations.
C) a solution containing detergent.
D) a solution of high ionic strength.
E) hot water.

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A protein is found to extend all the way through the membrane of a cell. Describe this protein in terms of the location of particular types of amino acid side chains in its structure and its ability to move within the membrane.

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The protein that extends all the way thr...

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What are the similarities and differences between integrins, cadherins, and selectins?

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Integrins, cadherins, and selectins are ...

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The bacterium E. coli can grow at 20 °C or at 40 °C. At which growth temperature would you expect the membrane phospholipids to have a higher ratio of saturated to unsaturated fatty acids, and why?

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At 20 °C, you would expect the membrane ...

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The inner (plasma) membrane of E. coli is about 75% lipid and 25% protein by weight. How many molecules of membrane lipid are there for each molecule of protein? (Assume that the average protein is Mr 50,000 and the average lipid is 750.)


A) 1
B) 50
C) 200
D) 10,000
E) 50,000

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