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One of the principal means by which the kidneys regulate acid-base balance is by increasing or decreasing the bicarbonate concentration of the blood.

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The principal buffer against acidosis during exercise is intracellular phosphate groups.

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Which of the following events occurs during exercise at work rates above 60-80% VO2 max?


A) a decrease in plasma bicarbonate concentration
B) an increase in blood lactic acid concentration
C) a decrease in blood pH
D) All of the above answers are correct

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Which of the extracellular buffers contributes the most to the cell's buffering capacity?


A) bicarbonate
B) hemoglobin
C) extracellular proteins
D) all of the above contribute equally

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An increase in the hydrogen ion concentration in contracting skeletal muscle can impair performance by hydrogen ions competing with calcium ions for binding sites on troponin.

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Repeated bouts of high intensity exercise (e.g. ,interval training) can reduce arterial pH to levels as low as


A) 7.3
B) 7.2
C) 7.1
D) None of the above answers are correct

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Which of the following events are not primary sources of hydrogen ions during rigorous exercise?


A) ATP breakdown and release of hydrogen ions
B) Increased production of lactic acid
C) Aerobic metabolism of glucose resulting in the production of carbonic acid
D) anaerobic production of 3-phosphoglucose during glycolysis

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Which of the following statements about a buffer is correct?


A) a buffer resists pH change
B) a buffer removes hydrogen ions from solution
C) buffers often consist of a weak acid and its conjugate base
D) All of the above answers are correct

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According to the Henderson-Hasselbalch equation,the pH of a weak acid solution is determined by


A) ratio of the concentration of the acid in solution to the concentration of the base
B) ratio of the concentration of the base in solution to the concentration of the acid
C) the dissociation constant of bicarbonate
D) All of the above answers are correct

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Acidosis can occur due to


A) a decrease in the H+ concentration.
B) a loss of acids from the blood.
C) an accumulation of bases in the blood.
D) none of the above.

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