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Several recent prospective, longitudinal studies have determined that individuals who have reported using cannabis as adolescents _________________ risk of developing schizophrenia or psychotic-like symptoms than nonusers several years later.


A) had roughly double the
B) exhibited the same
C) exhibited a lower

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There is now fairly general agreement that most of the primary hallucinogenic effects of LSD are mediated through which neurotransmitter system?


A) GABAergic
B) cholinergic
C) dopaminergic
D) serotonergic

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What potential hazard could be involved in using an antipsychotic drug like Thorazine in the treatment for an acute psychotic reaction to a hallucinogenic drug?

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Although antipsychotics such as Thorazine can reduce the effects of LSD and other monoamine-related hallucinogens, they can increase the mental confusion or intensify the experience induced by some hallucinogenic drugs, e.g., PCP or scopolamine.Thus if one does not know exactly what type of drug is causing the psychotic symptoms, it would not be prudent to use an antipsychotic to control the symptoms.

Delta-9-THC induces several effects


A) that are similar to those induced by LSD
B) that appear to be due to disruptions in the hippocampus of the brain
C) both a and b
D) neither a nor b above

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Which of the following is a specific endogenous ligand for cannabinoid receptors?


A) noradrenaline
B) anandamide
C) serotonin
D) dopamine

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Ibogaine


A) is a hallucinogenic drug used by Central-West Africans for a variety of purposes
B) has been proposed as a treatment for addiction to a variety of drugs
C) induces actions on a variety of neurotransmitter systems
D) all of these

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Which of the following produces symptoms that are most like those of a natural psychosis?


A) LSD
B) mescaline
C) phencyclidine (PCP)
D) delta-9-THC

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MDMA, which is commonly referred to as "ecstasy",


A) has been used by clinicians in an attempt to increase patient empathy and insight
B) in small doses induces effects indistinguishable from those of LSD
C) is a relatively recently designed hallucinogen
D) affects primarily dopaminergic receptors

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Primarily because of very low abuse potential, which of the following hallucinogens is not a schedule controlled substance?


A) LSD
B) mescaline
C) anticholinergics
D) psilocybin

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When the hallucinogens phencyclidine (PCP) and LSD are compared, it is generally the case that PCP is more likely to


A) induce anesthesia
B) elicit symptoms indistinguishable from schizophrenia
C) be self-administered by nonhumans
D) all of the above

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Cannabinoids


A) are chemicals unique to marijuana (cannabis)
B) are alkaloids
C) possess molecular structures similar to some of the monoamine neurotransmitters
D) are very water soluble

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Which of the following is consistent with there being specific receptors upon which the cannabinoid delta-9 THC acts?


A) it has high lipid solubility
B) modest structural modifications of the THC molecule can significantly alter its behavioral effects
C) it has stereospecific effects
D) only b and c above

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Delta-9-THC has been shown to


A) elevate extracellular levels of dopamine in the nucleus accumbens
B) be self-administered by non-human animals
C) be the major psychoactive compound in marijuana
D) all of these

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Using the drug discrimination procedure with animals, it has been determined that PCP (phencyclidine) has properties indistinguishable from those of


A) cholinergic drugs
B) serotonergic drugs
C) opioid drugs
D) none of these

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D

In which area is the LSD experience quite similar to schizophrenia?


A) the hallucinations are generally auditory and threatening
B) the person is highly resistant to suggestion
C) there is the appearance of ambivalence over interpersonal relationships
D) none of these

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The molecular structure of mescaline is most similar to which neurotransmitter?


A) serotonin
B) acetylcholine
C) catecholamines
D) GABA

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Which of the following statements regarding MDMA, commonly referred to as "ecstasy", is correct?


A) Some psychotherapists have used it in an attempt to increase empathy and insight in their patients.
B) With large doses it induces perceptual effects similar to those of LSD.
C) National surveys have indicated that its use by adolescents and young adults has increased dramatically over the past 15 years.
D) all of these

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An abstinence syndrome associated with marijuana use


A) has not been documented
B) can occur following high dosage use
C) is almost indistinguishable from that associated with chronic opiate use
D) is almost indistinguishable from that associated with chronic alcohol use

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What is a primary property of the antimuscarinic hallucinogens that likely accounts for the absence of their abuse?

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Their anticholinergic side eff...

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Which type of psychotomimetic is a nonhuman LEAST likely going to self-administer if given the opportunity?


A) LSD
B) phencyclidine (PCP)
C) delta-9-THC
D) MDMA (Ecstasy)

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A

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