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Epistasis and multiple alleles differ in that


A) epistasis is an interaction between two different chromosomes, and multiple alleles affect a single gene.
B) epistasis is an interaction between two genes, and multiple alleles are variants of the same gene.
C) epistasis affects males and multiple alleles occur in females.
D) epistasis only occurs in genes that have multiple alleles.
E) in epistasis one gene masks another, but one allele cannot mask the effect of another.

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Different alleles that are both expressed in a heterozygote are


A) dominant.
B) codominant.
C) incompletely dominant.
D) homozygous dominant.
E) automatically dominant.

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Geneticists construct linkage maps of chromosomes by


A) correlating a phenotype to an observable chromosomal abnormality.
B) determining the number of crossovers between genes on different chromosomes.
C) calculating the percent recombination between two genes on the same chromosome.
D) observing the number of genes on a chromosome.
E) observing environmental factors that cause a condition.

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Can a woman with blood type A have a child with blood type O with a man who is AB?


A) Yes, because of codominance between the IA and IB alleles.
B) No, because a man with type AB blood could not contribute an i allele.
C) Yes, because of epistasis between the I and the H genes.
D) No, because the child's genotype must be ii.
E) Cannot tell from the phenotypes.

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A widely-used research technique used to associate patterns of genetic variation with phenotypes that is based on the concept of linkage,but considering all of the chromosomes at once,is


A) gene expression profiling.
B) genome sequencing.
C) genome-wide association studies.
D) assisted reproductive technologies.
E) genetically modified organisms.

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Some combinations of recessive alleles cause problems so severe that the fetus ceases to develop.Such lethal allele combinations appear to alter Mendelian ratios because


A) the allele is masked in heterozygotes.
B) carriers do not constitute a progeny class.
C) they do not show a 1:2:1 genotypic ratio.
D) homozygotes for the lethal allele do not appear as a progeny class.
E) homozygotes for the lethal allele pass it on to half their offspring.

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Mitochondrial DNA differs from nuclear DNA in that it


A) crosses over within the same strand.
B) is inherited from the father only.
C) is present only in cells of the nervous and muscular systems.
D) it is poorer at DNA repair.
E) is present only in females.

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The mitochondrial genome consists of ___ genes.


A) 12
B) 37
C) 250
D) 370
E) 3,700.

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Types of genetic markers include


A) places in the genome where a base varies among individuals in a population.
B) places in the genome where all people have identical base sequences.
C) the types of mRNAs in a cell.
D) the proteins produced in a cell.
E) how many centromeres chromosomes have in a population.

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Hairlessness in dogs is inherited from a single dominant allele.Inheriting two dominant alleles is lethal for the embryo.Ralph and Penelope are both hairless dogs.What is the probability that Penelope will give birth to a hairy puppy?


A) 3/4
B) 1/3
C) 2/3
D) 1/4
E) 1/2

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A man who has normal hearing and has a recessive deafness allele on chromosome 17 marries a woman who also has normal hearing and also has a recessive deafness allele,but this allele is on chromosome 3.The probability that their children will be deaf due to either of these mutated genes is closest to


A) 100%.
B) 50%.
C) 25%.
D) 0%.
E) 200%.

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A trait caused by an environmental influence that appears to be inherited is


A) pleiotropic.
B) a phenocopy.
C) incompletely penetrant.
D) multigenic.
E) completely lethal.

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Mitochondrial disorders are probably very rare because


A) people have many mitochondria, so the healthy ones can substitute for the affected ones.
B) as oocytes formed, those with harmful mitochondrial mutations did not have sufficient energy to survive.
C) they are difficult to diagnose because most physicians have forgotten what mitochondria are.
D) they do not produce symptoms.
E) they are not inherited from the father.

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If allele T (long tongue) exhibits incomplete dominance over the recessive allele t (short tongue) ,a heterozygote for this gene would most likely have


A) a long tongue.
B) a short tongue.
C) a tongue that changes length.
D) a tongue of intermediate length.
E) a forked tongue.

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Which of the following is an illness caused by a mutation in mitochondrial DNA?


A) cystic fibrosis
B) Duchenne muscular dystrophy
C) hemophilia
D) Leber optic atrophy
E) Marfan syndrome

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A and B are linked genes.A heterozygote for both genes would show which configuration if the genes are in cis?


A) Abab\frac { A b } { a b }
B) AaBb\frac { A a } { B b }
C) ABab\frac { A B } { a b }
D) AbaB\frac { A b } { a B }
E) none of these choices

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C

Marfan syndrome can be caused by mutations in either of two genes,but mutations in one of the genes blocks activity of the other.This means that Marfan syndrome demonstrates


A) variable expressivity and complete penetrance.
B) an acquired phenotype.
C) late onset and early onset.
D) genetic heterogeneity and epistasis.
E) none of the above.

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Of nearly 200 forms of hereditary deafness,132 are autosomal recessive,64 autosomal dominant and 4 X-linked recessive.Hereditary deafness is therefore genetically


A) heterozygous.
B) heterogenic.
C) heterogametic.
D) heterosexual.
E) heterostatic.

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B

Multiple alleles are common because


A) RNA is an informational molecule, and many sequences are possible for a particular gene.
B) proteins are informational molecules, and many amino acid sequences are possible.
C) a gene sequence can vary in different ways and still encode a functional protein.
D) there are many humans on the planet.
E) people have many children.

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Marbles is a Manx cat whose tail is so short that she appears not to have one.The genotype for short tail in Manx cats is heterozygous (Mm) .Cats that are genotype mm have normal length tails,but cats that are genotype MM die before birth due to very abnormal brains and spinal cords.Marbles has one copy of a recessive _____ allele.


A) pleiotropic
B) penetrant
C) lethal
D) polymorphic
E) silent

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C

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