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Which type of vaccine has been used in place of inactivated whole cell vaccine?


A) acellular subunit
B) whole cell attenuated
C) adjuvant
D) toxin

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The effectiveness of DNA vaccines stems from the effective production of antibodies against the naked DNA molecule.

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The procedure developed by the Chinese to protect against smallpox was called


A) Oriental poxination.
B) humoral immunity.
C) variolation.
D) naturally acquired immunity.

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Injection of a single antigen usually results in production of


A) antibody to a single epitope.
B) an antibody that recognizes several epitopes.
C) additional antigen.
D) a number of antibodies each recognizing a different epitope.

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Active immunity develops only after a natural infection and not after vaccination.

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For which of the following childhood diseases is a subunit vaccine recommended?


A) polio
B) measles
C) hepatitis B
D) pertussis

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The change from negative serum, without antibodies specific to an infecting agent, to positive serum, containing antibodies against that infecting agent, is called


A) ELISA.
B) complement fixation.
C) seroconversion.
D) RIA.

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Inactivated vaccines typically require booster shots.

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Monoclonal antibodies


A) are usually of different classes.
B) usually recognize several epitopes.
C) have the same variable regions.
D) are always IgE.

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Monoclonal antibodies may be used in the rapid diagnosis of


A) pregnancy.
B) hepatitis.
C) influenza.
D) chlamydia.
E) All of the choices are correct.

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What would be a primary advantage of using an attenuated agent rather than just an antigen from that agent for a vaccine?


A) This is actually a disadvantage-it's much more dangerous to use an attenuated agent over a subunit (single antigen) vaccine due to the possibility of reversion of the microbe to a pathogenic state.
B) An attenuated agent strongly stimulates ONLY the antibody production (humoral response) of the adaptive immune system. This provides the best and strongest long-term protection.
C) An attenuated agent strongly stimulates ONLY the cytotoxic T cell (CTL, cell-mediated) side of the adaptive immune system. This provides the best and strongest long-term protection.
D) An attenuated agent strongly stimulates both the humoral (antibody) AND cell-mediated (T cell) portions of the adaptive immune response, giving the best comprehensive long-term protection available.

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Agglutination tests can be used to diagnose diseases caused by


A) bacteria.
B) hormones.
C) fungi.
D) viruses.
E) All of the choices are correct.

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Herd immunity


A) only occurs in a population in which all individuals are immune.
B) occurs in a population in which a large percentage of the population is immune.
C) only provides protection to those that are already immune.
D) is responsible for dramatic increases in childhood diseases.
E) occurs in a population in which a large percentage of the population is immune AND is responsible for dramatic increases in childhood diseases.

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Attenuated agents are


A) dead viruses.
B) toxins.
C) weakened live organisms.
D) parts of an organism.

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Variolation is a procedure once used to protect against


A) measles.
B) bubonic plague.
C) rabies.
D) smallpox.

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The practice of deliberately stimulating the immune system is called


A) acquired immunity.
B) memory immunity.
C) vaccination.
D) hypersensitivity.

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Monoclonal antibodies obtained from a hybridoma provide


A) a large amount of an antibody that is specific for a particular antigen.
B) a single antibody that recognizes many antigens.
C) many antigens that recognize a specific antibody.
D) a large number of B cells.

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The last case of naturally contracted smallpox occurred in


A) 1900.
B) 1950.
C) 1965.
D) 1977.
E) 1989.

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The virus originally used for vaccination against smallpox is named


A) vaccinia.
B) cowpox.
C) rubella.
D) herpes.

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DNA vaccines work by


A) stimulating production of antibodies against DNA.
B) stimulating interferon production.
C) inactivating the host DNA.
D) having the cell use the introduced DNA to make the microbial protein antigen.

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