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Describe the structure and function of the histone octamer.

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The winding of DNA around a core of eigh...

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What phenomenon allows for the generation of multiple distinct cell types?


A) combinatorial control
B) enhancer control
C) promoter control
D) epigenetic control
E) None of the answers is correct.

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What are the requirements for binding of the bromodomain to the transcriptional machinery?

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The bromodomain is also known as the ace...

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Which of the following are ways in which eukaryotic gene expression is more complex than prokaryotic gene expression?


A) different cell types that express only a subset of the genes in the genome
B) the lack of DNA binding proteins to direct gene expression
C) the inaccessibility of the DNA in chromatin
D) A and B are correct.
E) A and C are correct.

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Seventy percent of the cytosines in human DNA are modified by methylation specifically in _______________ sequences.

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Which of the following elements is found in the active site of the Argonaute-miRNA complex?


A) magnesium
B) calcium
C) zinc
D) iron
E) copper

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Describe the arrangement of histones and associated DNA in a nucleosome.

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Two copies of each of the four histone p...

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What are binding sites,present on DNA,that bind regulatory proteins,resulting in an increased level of transcription for a gene that is distant from the binding site?


A) promoter
B) enhancer
C) augmenter
D) amplifier
E) enlarger

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How does a coactivator function in gene expression?

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The binding of ligand to the receptor in...

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Histone binding and wrapping of DNA reduces the DNA length by


A) 2-fold.
B) 7-fold.
C) 20-fold.
D) 100-fold.
E) 1000-fold.

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