Question 1

Mutations in a normal growth-stimulating gene are most likely to have no effect or to cause

Accepted Answer

A)  the loss of responsiveness to growth stimulation in the cell with the mutant gene.
B)  the cell with the mutant gene to become cancerous.
C)  excessive growth in the cells surrounding the one with the mutant gene.
D)  a mutator effect in the cell with the mutant gene.
E)  apoptosis of the cell with the mutant gene.

Question 2

Cell proliferation in culture is normally limited by

Accepted Answer

A)  cytophagy.
B)  quorum sensing.
C)  contact inhibition.
D)  competition.
E)  nutrient limitation. C

Question 3

What kinds of cancers might eventually be treated with RNAi,which you learned about in

Accepted Answer

siRNAs can be engineered to silence or d...

Question 4

Hereditary retinoblastoma is an autosomal dominant hereditary cancer.Cells from retinal tumors in a child who has this disease possess

Accepted Answer

A)  evidence of non-disjunction in all autosomes.
B)  one non-functional copy of the retinoblastoma gene.
C)  two non-functional copies of the retinoblastoma gene.
D)  trisomy for the retinblastoma gene.
E)  a dominant mutation in the retinoblastoma gene.

Question 5

In normal cells,p53 protein acts as

Accepted Answer

A)  a signal transducer.
B)  a tumor suppressor.
C)  a proto-oncogene activator.
D)  a GTPase inhibitor.
E)  None of these

Question 6

Wild-type mutator genes produce substances that induce point mutations and chromosomal rearrangements.

Accepted Answer

A) True 
 B)False

Question 7

The products of tumor suppressor genes stimulate cell proliferation,while the products of proto-oncogenes inhibit cell proliferation.

Accepted Answer

A) True 
 B)False

Question 8

Terminally differentiated cells are noncancerous,normal cells.

Accepted Answer

A) True 
 B)False

Question 9

Cancer is best defined as

Accepted Answer

A)  immune dysfunction.
B)  uncontrolled and abnormal cell division.
C)  viral malignancy.
D)  regulated differentiation of tissue.
E)  cellular deregulation.

Question 10

Protein kinases are enzymes that normally catalyze the

Accepted Answer

A)  degradation of cellular proteins.
B)  phosphorylation of cellular proteins.
C)  formation of peptide bonds in proteins.
D)  phosphorylation of ADP.
E)  synthesis of kinins.

Question 11

Ionizing radiation is emitted at low levels by many natural objects,including some rocks and gases.

Accepted Answer

A) True 
 B)False

Question 12

Agents that can induce cancer through mutagenesis are called

Accepted Answer

A)  destabilizers.
B)  cancerogens.
C)  mutagens.
D)  carcinogens.
E)  None of these

Question 13

Apoptosis is

Accepted Answer

A)  rapid cell division.
B)  caused by proto-oncogenes.
C)  the change in shape of a cell when it becomes cancerous.
D)  programmed cell death.
E)  None of these D

Question 14

At the molecular level,what exactly are the mutagenic effects of UVA and UVB radiation?

Accepted Answer

The answer of At the molecular level,what exactly are the...

Question 15

What is metastasis,and why is metastatic cancer the most difficult cancer to treat?

Accepted Answer

Metastasis is the spreading of cancerous...

Question 16

The Bcl-2 gene product in its normal form can be activated to prevent cells from undergoing apoptosis (programmed cell death)in specific circumstances.It is a carefully regulated gene,being "turned on" only under specific circumstances.A null mutation in Bcl-2 leads to excessive cell loss.Some Bcl-2 mutation can cause a "gain of function" in which the protein is active all the time.
a.In the terms used in this chapter,what would the normal version be called?
b.What would the gain-of-function mutation be called?
c.How would you expect the gain-of-function mutation to be involved in cancer?

Accepted Answer

(a)A proto-oncogene. (b)An oncogene. (c)The gain-of-function mutation could cause abnormal cells to fail to commit suicide when their genome has been irreparably damaged.As a result,these cells could mutate into cancer cells.

Question 17

Match between columns
                        Premises: Proto-oncogenes
Cyclins
CDK
Oncogenes
Tumor suppressors

Accepted Answer

The Answer of Normal growth-promoting genes and Are made and is...

Question 18

Some carcinogens act on the genome directly,while others are converted to mutagenic substances by the cells's enzymes.

Accepted Answer

A) True 
 B)False

Question 19

The nucleic acid of retroviral provirus is composed of RNA.

Accepted Answer

A) True 
 B)False

Question 20

Which of the following statements is not true?

Accepted Answer

A)  Certain types of virus can cause cancer.
B)  Melanomas are commonly caused by ionizing radiation.
C)  Neoplasia is another term for cancerous cells.
D)  About half the people with cancer have a mutation in a p53 gene.
E)  Most cancers are hereditary.

Exam 20: Genetics of Cancer

Mutations in a normal growth-stimulating gene are most likely to have no effect or to cause

Correct Answer
verified

Cell proliferation in culture is normally limited by

Correct Answer
verified
C

What kinds of cancers might eventually be treated with RNAi,which you learned about in

Correct Answer
verified
siRNAs can be engineered to silence or d...
View Answer

Hereditary retinoblastoma is an autosomal dominant hereditary cancer.Cells from retinal tumors in a child who has this disease possess

Correct Answer
verified

In normal cells,p53 protein acts as

Correct Answer
verified

Wild-type mutator genes produce substances that induce point mutations and chromosomal rearrangements.

Correct Answer
verified

The products of tumor suppressor genes stimulate cell proliferation,while the products of proto-oncogenes inhibit cell proliferation.

Correct Answer
verified

Terminally differentiated cells are noncancerous,normal cells.

Correct Answer
verified

Cancer is best defined as

Correct Answer
verified

Protein kinases are enzymes that normally catalyze the

Correct Answer
verified

Ionizing radiation is emitted at low levels by many natural objects,including some rocks and gases.

Correct Answer
verified

Agents that can induce cancer through mutagenesis are called

Correct Answer
verified

Apoptosis is

Correct Answer
verified
D

At the molecular level,what exactly are the mutagenic effects of UVA and UVB radiation?

Correct Answer
verified

What is metastasis,and why is metastatic cancer the most difficult cancer to treat?

Correct Answer
verified
Metastasis is the spreading of cancerous...
View Answer

Correct Answer
verified
(a)A proto-oncogene. (b)An oncogene. (c)The gain-of-function mutation could cause abnormal cells to fail to commit suicide when their genome has been irreparably damaged.As a result,these cells could mutate into cancer cells.

Please select the best match for each term.

Some carcinogens act on the genome directly,while others are converted to mutagenic substances by the cells's enzymes.

Correct Answer
verified

The nucleic acid of retroviral provirus is composed of RNA.

Correct Answer
verified

Which of the following statements is not true?

Correct Answer
verified

Exam 20: Genetics of Cancer

Mutations in a normal growth-stimulating gene are most likely to have no effect or to cause

Correct AnswerverifiedShow Answer

Cell proliferation in culture is normally limited by

Correct AnswerverifiedC

What kinds of cancers might eventually be treated with RNAi,which you learned about in

Correct AnswerverifiedsiRNAs can be engineered to silence or d...View AnswerShow Answer

Hereditary retinoblastoma is an autosomal dominant hereditary cancer.Cells from retinal tumors in a child who has this disease possess

Correct AnswerverifiedShow Answer

In normal cells,p53 protein acts as

Correct AnswerverifiedShow Answer

Wild-type mutator genes produce substances that induce point mutations and chromosomal rearrangements.

Correct AnswerverifiedShow Answer

The products of tumor suppressor genes stimulate cell proliferation,while the products of proto-oncogenes inhibit cell proliferation.

Correct AnswerverifiedShow Answer

Terminally differentiated cells are noncancerous,normal cells.

Correct AnswerverifiedShow Answer

Cancer is best defined as

Correct AnswerverifiedShow Answer

Protein kinases are enzymes that normally catalyze the

Correct AnswerverifiedShow Answer

Ionizing radiation is emitted at low levels by many natural objects,including some rocks and gases.

Correct AnswerverifiedShow Answer

Agents that can induce cancer through mutagenesis are called

Correct AnswerverifiedShow Answer

Apoptosis is

Correct AnswerverifiedD

At the molecular level,what exactly are the mutagenic effects of UVA and UVB radiation?

Correct AnswerverifiedShow Answer

What is metastasis,and why is metastatic cancer the most difficult cancer to treat?

Correct AnswerverifiedMetastasis is the spreading of cancerous...View AnswerShow Answer

Correct Answerverified(a)A proto-oncogene. (b)An oncogene. (c)The gain-of-function mutation could cause abnormal cells to fail to commit suicide when their genome has been irreparably damaged.As a result,these cells could mutate into cancer cells.

Please select the best match for each term.

Some carcinogens act on the genome directly,while others are converted to mutagenic substances by the cells's enzymes.

Correct AnswerverifiedShow Answer

The nucleic acid of retroviral provirus is composed of RNA.

Correct AnswerverifiedShow Answer

Which of the following statements is not true?

Correct AnswerverifiedShow Answer

Correct Answer
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C

Correct Answer
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siRNAs can be engineered to silence or d...
View Answer

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verified

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D

Correct Answer
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Correct Answer
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Metastasis is the spreading of cancerous...
View Answer

Correct Answer
verified
(a)A proto-oncogene. (b)An oncogene. (c)The gain-of-function mutation could cause abnormal cells to fail to commit suicide when their genome has been irreparably damaged.As a result,these cells could mutate into cancer cells.

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified