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Degranulation of mast cells leads to A. decreased mucus production. B. constriction of blood vessels. C. lymph node swelling. D. constricted bronchioles.

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A.decreased mucus production.
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Predict why insect stings and medication injections more often provoke anaphylactic shock,as compared to other allergens found in food or in air.


A) The allergens go directly into the blood in large amounts, compared to allergens entering the digestive tract or respiratory tract.
B) Chemicals from insects cause a combination of antibody types to be produced, resulting in much larger amounts of total antibody.
C) Histamine is overproduced as a result of injected chemicals.
D) Chemicals injected as medications cause problems in immune response, resulting in a reduced immune coverage.

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In systemic lupus erythematosis (called lupus) ,complexes of antibody and antigen form,and these immune complexes insert themselves into small blood vessels,joints,heart,and kidney,causing damage to the organ tissue.The course of the disease is unpredictable,with periods of illness alternating with remissions.How is lupus,a type III autoimmune disease,similar to the tuberculin reaction,a type IV hypersensitivity reaction?


A) Both lupus and the tuberculin reaction utilize IgE in their mechanisms.
B) Both lupus and the tuberculin reaction are immediate hypersensitivities, occurring within a few hours.
C) Both lupus and the tuberculin reaction involve large amounts of antibody production.
D) The mechanism of both lupus and the tuberculin reaction involve large amounts of inflammatory chemicals released into tissue.

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Which type/s of hypersensitivities is IgG is involved with?


A) Anaphylaxis
B) Antibody-mediated
C) Immune complex-mediated
D) Both anaphylaxis and antibody-mediated.
E) Both antibody-mediated and immune complex-mediated.

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Many men make antibodies to sperm, resulting in destruction of sperm to the point of sterility. What would be the likely origin of this autoimmune disease?


A) T helper cells erroneously identify sperm cells as foreign invaders, triggering the T cytotoxic cells to start killing sperm.
B) Since sperm are not made until after puberty, the immune system cannot scan the antigens on the sperm for immune tolerance. After sperm are made and the immune system sees them, they are recognized as foreign.
C) Antigens on sperm cells are similar to antigens on a variety of bacteria like Streptococcus. After a strep throat caused by Streptococcus, the immune system produces antibodies to streptococcal antigens, which then cross react with sperm antigens and destroy them.
D) These antibodies are produced as a result of mutations in T lymphocytes, causing them to make large amounts of antibody.

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Allergic rhinitis is also known as asthma.

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The chemical mediator that causes prolonged bronchospasm,vascular permeability,and mucus secretion of asthmatic patients is ______.


A) histamine
B) leukotriene
C) platelet-activating factor
D) serotonin
E) prostaglandin

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Severe combined immunodeficiencies (SCIDs) are due to


A) autoantibodies.
B) failure of B-cell development and maturity.
C) congenital absence or immaturity of the thymus gland.
D) delayed hypersensitivity.
E) a genetic defect in the development of both T cells and B cells.

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Which of the following is not a possible explanation for the origin of autoimmune diseases?


A) Sequestered antigens
B) Forbidden clones
C) Molecular mimicry
D) The gut microbiome
E) All the choices are currently being investigated as possible explanations.

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A xenograft is graft tissue from a donor of one species transplanted to a recipient of another species.

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You have dermatitis triggered by a particular material in your socks.Your feet are covered with a really itchy rash,which has developed blisters over the last day or so.You had first worn them 2 to 3 days ago,and you did not launder them after buying them at the store.Finding some antihistamine medication in your bathroom cabinet,you decide to take it to relieve the itching rash.Which statement is true?


A) The anti-histamine will have no effect because once a type I hypersensitivity kicks in, it will last for a few days.
B) The rash will go away because the antihistamine neutralizes the histamine chemicals coming from mast cells in your skin.
C) The anti-histamine will have no effect on the rash because histamine is not the chemical mediator in this hypersensitivity.
D) The antihistamine will make the rash worse because it reacts with chemicals release by the lymphocytes in your skin, exacerbating the situation.

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Allergic patients receiving small,controlled injections of specific allergens are undergoing ______.


A) sensitization
B) desensitization
C) degranulation
D) tissue matching

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John,a Peace Corps worker in the country of Mali in Africa,was in a car accident while traveling through a rural area.He was treated at a tiny rural hospital,and due to his loss of blood,he required a transfusion.John has B- blood type and has never received a transfusion before.Which statement is correct regarding this scenario?


A) He can be given types O or B, no matter whether Rh- or Rh+. At this point in time, he does not have anti-Rh antibody. O has no antigens on the blood cells, so he is also safe to receive that type in addition to his own B type.
B) He can safely receive O- blood even though he makes anti-A antibodies.
C) He can be given A+ blood type in addition to B+. Rh- means that he makes no antibody to Rh.
D) The preferred blood type to give John, in addition to his own B type blood, would be AB. Both types of blood have the B antigen on the cells, so they would correspond to his own antigens. As for Rh, he can receive only Rh- blood since he would have a reaction against Rh+.

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All of the following are involved in type II hypersensitivity except ______.


A) IgM
B) complement
C) foreign cells
D) IgE
E) IgG

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Eczema is an autoimmune disorder.

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Contact dermatitis involves


A) a sensitizing and provocative dose.
B) an allergen entering the skin.
C) T lymphocytes secreting inflammatory cytokines.
D) the production of itchy papules and blisters.
E) All of the choices are correct.

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A female who is Rh-


A) can never have an Rh+ baby.
B) is at risk for a pregnancy resulting in hemolytic disease of the newborn.
C) inherited two dominant genes.
D) is in the majority of the population with regard to Rh status.

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Human blood types involve all of the following except


A) MHC genes.
B) inheritance of two of three possible alleles.
C) ABO antigen markers.
D) genes that code for an enzyme that adds a terminal carbohydrate to RBC receptors.
E) genetically determined glycoprotein markers.

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The allergen in poison ivy plants is an oil called urushiol.

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The study of diseases associated with excesses and deficiencies of the immune system is ______.


A) humoralpathology
B) hemopathology
C) epidemiology
D) immunopathology
E) histopathology

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