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A ratio of the dose of the drug that is toxic to humans versus the minimum effective dose for that pathogen is assessed to predict the potential for toxic drug reactions.This is called the ______.


A) Kirby-Bauer technique
B) antibiogram
C) E-test
D) minimum inhibitory concentration (MIC)
E) therapeutic index (TI)

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Each of the following results in drug resistance, except


A) a drug being pumped out of the cell.
B) a drug being used as a nutrient by the cell.
C) a drug binding site being altered.
D) a drug being inactivated.
E) a drug being blocked from entering the cell.

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The use of vaginal inserts of Lactobacillus to restore a healthy acidic environment is an example of ______.


A) prebiotics
B) probiotics
C) lantibiotics
D) phytobiotics
E) riboswitches

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The use of a drug to prevent imminent infection is called ______.


A) competitive inhibition
B) synergism
C) prebiotics
D) prophylaxis
E) lantibiotics

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Side effects that occur in patient tissues while they are on antimicrobial drugs include all of the following, except


A) development of resistance to the drug.
B) hepatotoxicity.
C) nephrotoxicity.
D) diarrhea.
E) deafness.

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The use of any chemical in the treatment, relief, or prophylaxis of a disease is called ______.


A) prophylaxis
B) chemotherapy
C) selective toxicity
D) nephrotoxicity
E) synergism

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It is better to use a broad-spectrum drug instead of a more specific, narrow-spectrum drug.

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Acyclovir is used to treat infections caused by ______.


A) influenza A virus
B) HIV
C) herpes simplex virus
D) respiratory syncytial virus
E) hepatitis C virus

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An antibiotic of the penicillin family is penicillin G.

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Sulfonamides are analogs of PABA and, as a result, they inhibit _____ synthesis.


A) protein
B) DNA
C) RNA
D) folic acid
E) phospholipid

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Which of the following antimicrobials does not inhibit DNA synthesis?


A) Chloroquine
B) Quinolone
C) Penicillin
D) Azidothymidine
E) Acyclovir

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Each of the following target bacterial ribosomes, except ______.


A) streptomycin
B) gentamycin
C) polymyxins
D) tetracycline
E) erythromycin

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Drug susceptibility testing determines


A) the patient's response to various antimicrobials.
B) the pathogen's response to various antimicrobials.
C) if normal biota will be affected by antimicrobials.
D) if the drug is increasing to toxic levels in a patient.

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Primaquine and chloroquine are drugs used in the treatment of ______ infections.


A) gram-positive bacterial
B) gram-negative bacterial
C) fungal
D) protozoan
E) viral

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Drug toxicity occurs when an antimicrobial drug acts as antigen and stimulates an allergic response.

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A patient has a staphylococcal infection of the blood; a septicemia - very serious and possibly deadly.As the doctor, you would like to prescribe a relatively non-toxic and inexpensive drug out of the cephalosporin family.However, if the patient harbors a strain of Staphylococcus that is resistant to a variety of antibiotics, you would prefer to use vancomycin-- which is highly effective against Staphylococcus.Which of the following explains why the cephalosporin drug is preferred for use over the vancomycin?


A) You would rather give an inexpensive drug to save the family money.
B) You really do not know that much about vancomycin, so you would rather go with a drug that you can find out more about.
C) Vancomycin is very toxic, and the Staphylococcus strain could become resistant leaving no back-up drugs with which to treat the infection.
D) Vancomycin is one of the most selectively toxic drugs there is, so you would prefer one that has a more broad-spectrum effect.

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Antimicrobials effective against a wide variety of microbial types are termed ______.


A) antibiotics
B) narrow-spectrum drugs
C) semisynthetic drugs
D) synthetic drugs
E) broad-spectrum drugs

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Microbial resistance resulting from mutation occurs because


A) bacterial genomes undergo mutation rapidly.
B) bacterial genomes undergo mutation often.
C) short generation times accumulate mutations in populations.
D) mutations are passed between organisms.
E) All of the choices are correct.

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The use of antibiotics in cattle feed leads to the development of antibiotic-resistant bacteria.

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Which of the following is not an aminoglycoside?


A) Streptomycin
B) Gentamicin
C) Tetracycline
D) Amikacin
E) Tobramycin

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