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Which of the following statements concerning the genetic code is false?


A) It is based on triplets.
B) It is non-overlapping.
C) Commas are used.
D) It is degenerate.

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How many codons are known for each amino acid?


A) 1 only
B) 2 only
C) 2 to 4 depending on the nature of the amino acid
D) 1 to 6 depending on the nature of the amino acid

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What is the maximum number of amino acids that can be specified by a codon consisting of a sequence of two bases?


A) 4
B) 8
C) 16
D) 20

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There is no codon for the amino acid hydroxyproline,but this amino acid is a prominent feature of collagen structure.Which of the following is a likely explanation?


A) Hydroxyproline is substituted for proline after translation by a cut and patch mechanism.
B) Proline is covalently modified to give hydroxyproline after translation.
C) There is an alternative mechanism for synthesis of proteins that contain hydroxyproline.
D) It is not possible to form a hypothesis from the information given.

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Which of the following is true concerning protein synthesis and memory?


A) Animals that cannot make new proteins have no memories
B) Inhibition of protein synthesis in eukaryotes leads to lack of long term memory
C) Production of CREB is inhibited when strong memories are made
D) none of these is true

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Wobble allows a single codon to code for more than one amino acid.

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Specificity of aminoacyl-tRNA synthetases is always based on the anticodon.

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Which amino acids have unique codons?


A) met, gly
B) trp, met
C) tyr, met
D) stop, his

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After peptide bond formation takes place,what step is necessary for continuation of protein synthesis?


A) binding of uncharged tRNA to the ribosome
B) binding of EF-Tu
C) binding of EF-Ts
D) translocation of the ribosome

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Each tRNA molecule has a separate activating enzyme.

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What is the mode of action of puromycin in the inhibition of protein synthesis?


A) inhibition of peptidyl transferase
B) inactivation of EF-G
C) termination of the growing polypeptide chain
D) dissociation of mRNA from the ribosome

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Which category of RNA carries amino acids for the process of translation?


A) mRNA
B) rRNA
C) snRNA
D) tRNA

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What type of assay using tRNAs and ribosomes enabled complete determination of the genetic code?


A) filter binding assays
B) high performance chromatography
C) electrophoresis
D) density gradient centrifugation

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Amino acids linked to the 2'-end of a tRNA


A) are regular substrates for protein synthesis.
B) are transferred to the 3' position prior to their use in protein synthesis.
C) are prompted hydrolysed off as part of a proofreading mechanism.
D) never occur.

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At what point does the formylation reaction take place to produce N-formylmethionine?


A) On the free amino acid prior to its addition to a tRNA.
B) After methionine has been added to a specific tRNA.
C) After the methionine-tRNA adduct has complexed with the ribosome.
D) After the first peptide bond is formed on the ribosome.

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How many codons are possible in a system in which a sequence of three bases specifies a single amino acid?


A) 20
B) 24
C) 27
D) 64

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The template for protein synthesis is:


A) a mRNA strand
B) the DNA coding strand
C) the DNA template strand
D) a protein primer
E) none of these

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The actual functions of the factors in eukaryotes are similar to the functions of these factors in bacteria.

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The match between codon and anticodon is one of the many proofreading aspects of protein synthesis.

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At which position on tRNA is the wobble base of the triplet anticodon?


A) 1st position (5' letter)
B) 2nd position
C) 3rd position (3' letter)
D) Wobble can occur at any position.

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