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Exam 16: Hypoproliferative Anemias

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Question 1

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Diamond-Blackfan syndrome anemia is a rare congenital progressive erythrocyte aplasia.What is the most probable defect causing this rare disorder?

A) Deficiency of erythropoietin
B) Antibodies against erythropoietin
C) Intrinsic defect of erythroid progenitor cells
D) Increased reticulocytes

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Question 2

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Hypoproliferative anemia is defined as:

A) Decreased hematopoiesis in the bone marrow
B) Decreased hematopoiesis in the liver
C) Decreased erythropoiesis in the bone marrow
D) Ineffective erythropoiesis in the bone marrow

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Question 3

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Correlate the prognosis associated with the following treatments for aplastic anemia. a.Bone marrow transplant b.Cytokine therapy c.Stem cell transplant d.Immunosuppression therapy

Fanconi's syndrome is an example of:

Which of the following treatments offers the best prognosis for aplastic anemia?

Laboratory findings include a blood urea nitrogen >30 mg/dL,serum ferritin levels higher than normal,and a normocytic,normochromic morphology.What cause can be attributed to the anemia?

Anemia in hypersplenism differs from anemia found in true hypoproliferative anemias because in hypersplenism,there is:

Aplastic anemia in the acquired form can result from drugs or chemical agent exposure.If the link cannot be made to any environmental factor,what form of anemia does the client have?

Aplastic anemia is usually first noted by bleeding and the presence of petechial hemorrhages.What clinical sign in the early stages of the disease should cause doubt on the diagnosis of aplastic anemia?

Which of the following describes the bone marrow in a patient with Fanconi's syndrome?

Which of the following puts a patient taking chloramphenicol at risk for developing aplastic anemia?

What is a viable explanation as to why some individuals suffer stem cell damage when exposed to chemical agents but others do not?

A 3-month-old infant is exhibiting pallor and fatigue.The pediatrician orders a CBC,which displays a low RBC count,H&H,and normal WBC and PLT counts.EPO levels are increased.BM aspirate shows prominent erythroid hypoplasia.Cytogenetic analysis reveals the presence of RPS19 mutation.Based on these findings,what is the patient most likely suffering from?

Which of the following is among the diagnostic criteria for aplastic anemia?

Recent evidence suggests that the pathophysiology of most cases of acquired aplastic anemia is most likely:

Explain how exposure to the following can lead to aplastic anemia. a.Chloramphenicol b.Benzene c.Gamma radiation d.Starvation

Which CDA is characterized by a positive Ham test and a negative sucrose lysis test?

Define constitutional aplastic anemia,and give an example.

All of the following are considered diagnostic criteria for aplastic anemia except:

The presence of what poikilocyte would lead to a suspicion of myelophthisic anemia rather than pure red cell aplasia?