Question 1

Which statement best describes bioavailability

Accepted Answer

A)   All
B)   Measurement of the rate and amount of the unchanged drug reaches the systemic circulation
C)   Amount of the drug destroyed in the liver before entering systemic circulation
D)   Measurement of the relative toxicity of the preparation
E)   Movement of drug into body tissues over time

Question 2

In case of severe renal dysfunction, the duration of action of most drugs:

Accepted Answer

A)   Increases
B)   Decreases
C)   Will not changeDone by: Fawzi Shihadeh, Malik Sulima

Question 3

Half-life (t %)  doesn't depend on:

Accepted Answer

A)   Rate of metabolism
B)   Concentration of a drug in plasma
C)   Rate of drug elimination
D)   Time of drug absorption

Question 4

AII the following statements are correct concerning intravenous drug administration EXCEPT

Accepted Answer

A)   It is painful and stressful for the patient
B)   Drugs undergo first-pass metabolism
C)   A trained staff is required
D)   Risk of bacterial contamination at the site of injection

Question 5

In relation to the therapeutic window of a drug, which of the following sentences is true:

Accepted Answer

A)   Drugs with wide therapeutic range are not potent enough compared with narrow therapeutic range.
B)   A drug must exceed the maximum effective dose in order to be therapeutically active.
C)   Drugs with plasma concentration below the minimum effective concentration show no therapeutic effect.
D)   It is a range of concentration that determines both the safety and efficacy of drugs.

Question 6

The volume of distribution of gentamicin, a highly polar watersoluble drug, is 14L
Per 70 kg. This reflects the distribution of gentamicin into?

Accepted Answer

A)   Plasma
B)   Plasma, and interstitial fluid (extracellular) 
C)   Interstitial fluid
D)   Total body water
E)   Adipose tissue

Question 7

Drug X produces maximal contraction of cardiac muscle in a manner similar to epinephrine. Drug X is considered to be a/an?

Accepted Answer

A)   Partial agonist
B)   Irreversible antagonist
C)   Agonist
D)   Inverse agonist

Question 8

For continuous intravenous infusion as method of administration the time needed to achieve the concentration of steady state depends on the rate of drug administration?

Accepted Answer

A) True 
 B)False

Question 9

Tick the second messenger of G-protein-coupled (metabotropic)  receptor ?

Accepted Answer

A)   Adenylyl cyclase
B)   Sodium ions
C)   Phospholipase C
D)  cAmp

Question 10

Patient's age may affect a drug elimination

Accepted Answer

A) True 
 B)False

Question 11

Which of the following statements is the closest description of Phase! metabolism?

Accepted Answer

A)   Reactions which add an endogenous polar molecule to a functional group already present on a drug or one of its metabolites.
B)   Reactions which occur in the blood supply.
C)   Reactions which add a polar functional group to a drug
D)   Reactions which occur in the gut wall.

Question 12

The volume of distribution (Va)  for a drug highly bound to plasma protein as compared to others would be?

Accepted Answer

A)   High
B)   Low
C)   Unchanged
D)   Cannot be determined, it's an apparent parameter

Question 13

The term "chemical antagonism" means that?

Accepted Answer

A)   Two drugs combine with one another to form an inactive compound
B)   Two drugs combine with one another to form a more active compound
C)   Two drugs combine with one another to form a more water soluble compound
D)   Two drugs combine with one another to form a more fat soluble compound

Question 14

What does the term "bioavailability" mean?

Accepted Answer

A)   Plasma protein binding degree of substance
B)   Permeability through the brain-blood barrier
C)   Fraction of an uncharged drug reaching the systemic circulation following any route administration
D)   Amount ofa substance in urine relative to the initial dose

Question 15

Enzyme inhibitors such as Cimetidine and Erythromycin are likely to produce?

Accepted Answer

A)   Increase rate of breakdown of some drugs
B)   Increase free level of some drugs
C)   Inhibition of certain enzymes. which break down some drugs.
D)   Improvement of bioavailability of some drugs

Question 16

Ampicillin is eliminated by first-order kinetics. Which of the following statements best describes the process by which the plasma concentration of this drug declines

Accepted Answer

A)   The drug is distributed to only 1 compartment outside the vascular system
B)   The drug is largely metabolized in the liver after oral administration and has low bioavailability
C)   The rate of elimination is proportional to the rate of administration at all times
D)   The halflife is the same regardless of the plasma concentration

Question 17

The same dose of Four different drugs was administered IV to the same lab animal on four different occasions. The following pharmacokinetic data were obtained: Drug Plasma concentration) : for drug A 25 ng/mL Drug B: 12 ng/mL Drug C: 44 ng/mL Drug D:90ng/ml. which of the following drugs will have the lowest Vd the following drugs will have the lowest Vd

Accepted Answer

A)   Drug C
B)   Drug B
C)   Drug A
D)   DrugD

Question 18

All of the following statements are true about intranasal route of administration EXCEPT:

Accepted Answer

A)   It is only used for administration of drugs used in respiratory conditions.
B)   It has a rapid onset of action.
C)   It possesses good compliance among patients
D)   Few systemic side effects

Question 19

Which of the following drugs/or substances may inhibit the hepatic microsomal P450 responsible for the metabolism of substrate drugs

Accepted Answer

A)   Grapefruit juice
B)   Ethanol
C)   Rifampin
D)   Smoking

Question 20

The therapeutic range is the range of plasma drug concentrations that clearly defines optimal drug therapy and where adverse effects cannot occur.

Accepted Answer

A) True 
 B)False

Exam 1: Understanding Pharmacokinetics and Drug Administration

The volume of distribution (Va) for a drug highly bound to plasma protein as compared to others would be?

Correct Answer
verified

Half-life (t %) doesn't depend on:

Correct Answer
verified

AII the following statements are correct concerning intravenous drug administration EXCEPT

Correct Answer
verified

Ampicillin is eliminated by first-order kinetics. Which of the following statements best describes the process by which the plasma concentration of this drug declines

Correct Answer
verified

In relation to the therapeutic window of a drug, which of the following sentences is true:

Correct Answer
verified

Drug X produces maximal contraction of cardiac muscle in a manner similar to epinephrine. Drug X is considered to be a/an?

Correct Answer
verified

Which of the following drugs/or substances may inhibit the hepatic microsomal P450 responsible for the metabolism of substrate drugs

Correct Answer
verified

Which of the following statements is the closest description of Phase! metabolism?

Correct Answer
verified

In case of severe renal dysfunction, the duration of action of most drugs:

Correct Answer
verified

Patient's age may affect a drug elimination

Correct Answer
verified

The therapeutic range is the range of plasma drug concentrations that clearly defines optimal drug therapy and where adverse effects cannot occur.

Correct Answer
verified

Which statement best describes bioavailability

Correct Answer
verified

Enzyme inhibitors such as Cimetidine and Erythromycin are likely to produce?

Correct Answer
verified

The volume of distribution of gentamicin, a highly polar watersoluble drug, is 14L Per 70 kg. This reflects the distribution of gentamicin into?

Correct Answer
verified

Correct Answer
verified

For continuous intravenous infusion as method of administration the time needed to achieve the concentration of steady state depends on the rate of drug administration?

Correct Answer
verified

The term "chemical antagonism" means that?

Correct Answer
verified

Tick the second messenger of G-protein-coupled (metabotropic) receptor ?

Correct Answer
verified

What does the term "bioavailability" mean?

Correct Answer
verified

All of the following statements are true about intranasal route of administration EXCEPT:

Correct Answer
verified

Exam 1: Understanding Pharmacokinetics and Drug Administration

The volume of distribution (Va) for a drug highly bound to plasma protein as compared to others would be?

Correct AnswerverifiedShow Answer

Half-life (t %) doesn't depend on:

Correct AnswerverifiedShow Answer

AII the following statements are correct concerning intravenous drug administration EXCEPT

Correct AnswerverifiedShow Answer

Ampicillin is eliminated by first-order kinetics. Which of the following statements best describes the process by which the plasma concentration of this drug declines

Correct AnswerverifiedShow Answer

In relation to the therapeutic window of a drug, which of the following sentences is true:

Correct AnswerverifiedShow Answer

Drug X produces maximal contraction of cardiac muscle in a manner similar to epinephrine. Drug X is considered to be a/an?

Correct AnswerverifiedShow Answer

Which of the following drugs/or substances may inhibit the hepatic microsomal P450 responsible for the metabolism of substrate drugs

Correct AnswerverifiedShow Answer

Which of the following statements is the closest description of Phase! metabolism?

Correct AnswerverifiedShow Answer

In case of severe renal dysfunction, the duration of action of most drugs:

Correct AnswerverifiedShow Answer

Patient's age may affect a drug elimination

Correct AnswerverifiedShow Answer

The therapeutic range is the range of plasma drug concentrations that clearly defines optimal drug therapy and where adverse effects cannot occur.

Correct AnswerverifiedShow Answer

Which statement best describes bioavailability

Correct AnswerverifiedShow Answer

Enzyme inhibitors such as Cimetidine and Erythromycin are likely to produce?

Correct AnswerverifiedShow Answer

The volume of distribution of gentamicin, a highly polar watersoluble drug, is 14L Per 70 kg. This reflects the distribution of gentamicin into?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

For continuous intravenous infusion as method of administration the time needed to achieve the concentration of steady state depends on the rate of drug administration?

Correct AnswerverifiedShow Answer

The term "chemical antagonism" means that?

Correct AnswerverifiedShow Answer

Tick the second messenger of G-protein-coupled (metabotropic) receptor ?

Correct AnswerverifiedShow Answer

What does the term "bioavailability" mean?

Correct AnswerverifiedShow Answer

All of the following statements are true about intranasal route of administration EXCEPT:

Correct AnswerverifiedShow Answer

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