Question 1

Which of the following is the CORRECT relationship?

Accepted Answer

A)  PIP2 = PIP3 - DAG
B)  PIP2 = IP3 + DAG
C)  PLC = PIP2 + PIP3
D)  DAG = PIP2 + PIP3
E)  PIP3 = IP3 + PIP2

Question 2

In the research laboratory, you observe that B cells, cytotoxic T cells and mast cells begin to proliferate when exposed to IL-4.In this case, this effect of IL-4 may be described as

Accepted Answer

A)  synergy.
B)  antagonism.
C)  redundancy.
D)  pleiotrophy.
E)  both redundancy and pleiotrophy.

Question 3

Receptors that bind the constant regions of antibodies are known as

Accepted Answer

A)  B-cell receptors.
B)  T-cell receptors.
C)  idiotype receptors.
D)  toll-like receptors.
E)  Fc receptors.

Question 4

Receptors that dimerize upon ligand binding often contain _____ in their cytoplasmic domains.

Accepted Answer

A)  tyrosine kinases
B)  hydrophobic regions
C)  proteases
D)  metal-binding regions
E)  large immunoglobulin folds

Question 5

The antigen specific component of the B-cell receptor is

Accepted Answer

A)  ITAM.
B)  CD19.
C)  Ig ? / . ?
D)  CD21.
E)  Lyn.

Question 6

Which of the following BEST describes why it is challenging for surface immunoglobulin to transduce a signal into the cell upon antigen binding?

Accepted Answer

A)  It takes twice as much antigen to stimulate the cells because each antibody has two antigen binding sites.
B)  The cytoplasmic domain of surface Ig only has three amino acids.
C)  Ig ? is rapidly dephosphorylated.
D)  Ig is an inflexible molecule.
E)  All of the answers are correct.

Question 7

Which of the provided disassociation constants is MOST likely to be observed from an antibody binding an antigen during an immune response involving memory B cells?

Accepted Answer

A)  10-3 M
B)  10-5 M
C)  10-2 M
D)  10-10 M
E)  Antibody-antigen interactions cannot be measured.

Question 8

Which transcription factor becomes translocated to the nucleus downstream of calmodulin activation?

Accepted Answer

A)  NF- ? B
B)  NFAT
C)  STAT1
D)  STAT2
E)  STAT3

Question 9

Immunoglobulin domains consist of

Accepted Answer

A)  a series of ? helices bound together by hydrophobic interactions in their side chains.
B)   ? helices alternating with parallel ? -pleated sheets.
C)  Antiparalle ? l -pleated sheets folded and stabilized by hydrophobic interactions.
D)  Compact ? -parallel sheets forming a barrel structure.
E)   ?Helices held together by leucine repeats.

Question 10

Compare the locations of the antigen receptors of innate versus adaptive immunity.Which has the GREATEST variety?

Accepted Answer

Innate.Although both innate and adaptive...

Question 11

Imagine you are observing, at the molecular scale, interactions that occur when a dendritic cell activates a naïve CD4+ T cell.If the dendritic cell were exposed to an agent that disrupts the microtubule portion of the cytoskeleton prior to interaction, what would be the impact on T-cell activation?

Accepted Answer

The activation would likely be significa...

Question 12

On the gel below, which bands would you expect to bind antigen?
​

Accepted Answer

A)  B and A
B)  B and B
C)  B and C
D)  B and D
E)  B and A, B, and C

Question 13

Large amounts of monoclonal antibodies in the serum of an individual might be an indicator of

Accepted Answer

A)  infection.
B)  T-cell deficiency.
C)  autoimmune disease.
D)  myeloma.
E)  stress.

Question 14

The B-cell receptor has structural and functional elements.How would you describe the B-cell receptor from both a structural and functional perspective?

Accepted Answer

The B-cell receptor can be divided into ...

Question 15

Which of the following isotypes of antibodies is the largest?

Accepted Answer

A)  IgM
B)  IgG
C)  IgA
D)  IgE
E)  IgD

Question 16

Can you think of a functional property of chemokines that allows them to induce the directed movement of leukocytes to a site of inflammation from the circulation?

Accepted Answer

At least a few chemokines display an inn...

Question 17

The end results of signal transduction are varied but can include

Accepted Answer

A)  Induction of cell division.
B)  Cellular differentiation.
C)  Altered metabolism.
D)  Altered protein secretion patterns.
E)  All of the answers are correct.

Question 18

The biological outcomes of immune system recognition can include

Accepted Answer

A)  migration of leukocytes into infected tissues.
B)  clearance of a pathogen by an activated macrophage.
C)  promotion of optimal antigen presentation.
D)  induction of long-lived B and T cells.
E)  All of the answers are correct.

Question 19

Receptors that are multivalent tend to bind to their ligands more strongly than receptors with a single binding site.What is the term used to describe this phenomenon?

Accepted Answer

A)  Avidity
B)  Valency
C)  Affinity
D)  Magnetism
E)  None of the answers are correct.

Question 20

Whether an immunoglobulin is secreted or membrane bound is directly determined by

Accepted Answer

A)  the sequence of the DNA in the Ig locus.
B)  mRNA splicing.
C)  the kind of B cell that is producing it.
D)  DNA rearrangement.
E)  GPI anchors.

Exam 3: Recognition and Response

Whether an immunoglobulin is secreted or membrane bound is directly determined by

Correct Answer
verified

Receptors that dimerize upon ligand binding often contain _____ in their cytoplasmic domains.

Correct Answer
verified

The end results of signal transduction are varied but can include

Correct Answer
verified

Receptors that are multivalent tend to bind to their ligands more strongly than receptors with a single binding site.What is the term used to describe this phenomenon?

Correct Answer
verified

Which of the following BEST describes why it is challenging for surface immunoglobulin to transduce a signal into the cell upon antigen binding?

Correct Answer
verified

Correct Answer
verified
The activation would likely be significa...
View Answer

The antigen specific component of the B-cell receptor is

Correct Answer
verified

Which of the following is the CORRECT relationship?

Correct Answer
verified

Compare the locations of the antigen receptors of innate versus adaptive immunity.Which has the GREATEST variety?

Correct Answer
verified
Innate.Although both innate and adaptive...
View Answer

Immunoglobulin domains consist of

Correct Answer
verified

Which of the provided disassociation constants is MOST likely to be observed from an antibody binding an antigen during an immune response involving memory B cells?

Correct Answer
verified

The biological outcomes of immune system recognition can include

Correct Answer
verified

Large amounts of monoclonal antibodies in the serum of an individual might be an indicator of

Correct Answer
verified

In the research laboratory, you observe that B cells, cytotoxic T cells and mast cells begin to proliferate when exposed to IL-4.In this case, this effect of IL-4 may be described as

Correct Answer
verified

On the gel below, which bands would you expect to bind antigen?

Correct Answer
verified

Which transcription factor becomes translocated to the nucleus downstream of calmodulin activation?

Correct Answer
verified

Receptors that bind the constant regions of antibodies are known as

Correct Answer
verified

Can you think of a functional property of chemokines that allows them to induce the directed movement of leukocytes to a site of inflammation from the circulation?

Correct Answer
verified
At least a few chemokines display an inn...
View Answer

Which of the following isotypes of antibodies is the largest?

Correct Answer
verified

The B-cell receptor has structural and functional elements.How would you describe the B-cell receptor from both a structural and functional perspective?

Correct Answer
verified
The B-cell receptor can be divided into ...
View Answer

Exam 3: Recognition and Response

Whether an immunoglobulin is secreted or membrane bound is directly determined by

Correct AnswerverifiedShow Answer

Receptors that dimerize upon ligand binding often contain _____ in their cytoplasmic domains.

Correct AnswerverifiedShow Answer

The end results of signal transduction are varied but can include

Correct AnswerverifiedShow Answer

Receptors that are multivalent tend to bind to their ligands more strongly than receptors with a single binding site.What is the term used to describe this phenomenon?

Correct AnswerverifiedShow Answer

Which of the following BEST describes why it is challenging for surface immunoglobulin to transduce a signal into the cell upon antigen binding?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedThe activation would likely be significa...View AnswerShow Answer

The antigen specific component of the B-cell receptor is

Correct AnswerverifiedShow Answer

Which of the following is the CORRECT relationship?

Correct AnswerverifiedShow Answer

Compare the locations of the antigen receptors of innate versus adaptive immunity.Which has the GREATEST variety?

Correct AnswerverifiedInnate.Although both innate and adaptive...View AnswerShow Answer

Immunoglobulin domains consist of

Correct AnswerverifiedShow Answer

Which of the provided disassociation constants is MOST likely to be observed from an antibody binding an antigen during an immune response involving memory B cells?

Correct AnswerverifiedShow Answer

The biological outcomes of immune system recognition can include

Correct AnswerverifiedShow Answer

Large amounts of monoclonal antibodies in the serum of an individual might be an indicator of

Correct AnswerverifiedShow Answer

In the research laboratory, you observe that B cells, cytotoxic T cells and mast cells begin to proliferate when exposed to IL-4.In this case, this effect of IL-4 may be described as

Correct AnswerverifiedShow Answer

On the gel below, which bands would you expect to bind antigen? ​

Correct AnswerverifiedShow Answer

Which transcription factor becomes translocated to the nucleus downstream of calmodulin activation?

Correct AnswerverifiedShow Answer

Receptors that bind the constant regions of antibodies are known as

Correct AnswerverifiedShow Answer

Can you think of a functional property of chemokines that allows them to induce the directed movement of leukocytes to a site of inflammation from the circulation?

Correct AnswerverifiedAt least a few chemokines display an inn...View AnswerShow Answer

Which of the following isotypes of antibodies is the largest?

Correct AnswerverifiedShow Answer

The B-cell receptor has structural and functional elements.How would you describe the B-cell receptor from both a structural and functional perspective?

Correct AnswerverifiedThe B-cell receptor can be divided into ...View AnswerShow Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
The activation would likely be significa...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
Innate.Although both innate and adaptive...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

On the gel below, which bands would you expect to bind antigen?

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
At least a few chemokines display an inn...
View Answer

Correct Answer
verified

Correct Answer
verified
The B-cell receptor can be divided into ...
View Answer