Question 1

Examine Figure 7-4.(in the text) Can you summarize, in two sentences maximum, what this figure demonstrates about MHC I-peptide antigen interactions?

Accepted Answer

The ability of MHC I to bind to a divers...

Question 2

Suppose an individual is deficient in TAP (transporter associated with antigen processing).Is the deficiency MORE likely to produce symptoms of immune deficiency or autoimmunity in the person?

Accepted Answer

Both are possible.TAP is impor...

Question 3

How many different MHC classical class I proteins does each nucleated cell in a human heterozygous at the MHC locus express?

Accepted Answer

A)  None.Only APC express class I.
B)  One
C)  Two
D)  Three
E)  Six

Question 4

T-cell activation can be inhibited by treating antigen-presenting cells with chloroquine.What is chloroquine's mechanism of action?

Accepted Answer

A)  It blocks protein synthesis.
B)  It disrupts the Golgi apparatus.
C)  It increases the pH of the lysosome.
D)  It blocks TLR signaling.
E)  All of the answers are correct.

Question 5

Name an advantage of presenting viral antigens by both the endogenous and exogenous pathways.

Accepted Answer

During an active viral infection, typica...

Question 6

Your chances of having the same MHC haplotype as your sibling are

Accepted Answer

A)  1:1.
B)  1:2.
C)  1:4.
D)  1:8.
E)  1:16.

Question 7

MHC diversity ultimately affects the

Accepted Answer

A)  variety of peptides that bind to MHC.
B)  variety of BCRs that are expressed on mature B cells.
C)  rate of somatic hypermutation.
D)  number of antigen-presenting cells.
E)  transmembrane domain.

Question 8

Based on your knowledge of MHC I and II, predict which cell type would be MOST likely not to express detectable MHC I.

Accepted Answer

A)  Dendritic cells
B)  Macrophages
C)  Erythrocytes
D)  Intestinal epithelial cells
E)  Basophils

Question 9

A mutation in which part of a viral protein might allow the virus to evade the adaptive immune response because of its MHC binding?

Accepted Answer

A)  A TCR contact residue
B)  A residue in the transmembrane domain of an envelope protein
C)  A residue in the DNA-binding domain
D)  An anchor residue
E)  An amino acid on the surface of the virus

Question 10

Which of the following would be the MOST likely source of a peptide bound to an MHC class I molecule?

Accepted Answer

A)  The Golgi apparatus
B)  Outside the cell
C)  The endosome/lysosome
D)  The cytoplasm
E)  The chloroplast

Question 11

One way a developing fetus is protected from attack by the maternal immune system is

Accepted Answer

A)  expression of paternal MHC class I molecules.
B)  expression of paternal MHC class II molecules.
C)  expression of nonclassical class I molecules.
D)  expression of nonclassical class II molecules.
E)  expression of class III MHC molecules.

Question 12

Of the antigen receptors listed here - T-cell receptor, B-cell receptor, MHC I, and MHC II - which would you describe as "promiscuous" in their ligand-binding activity?

Accepted Answer

MHC I and MHC II.Any given MHC can bind ...

Question 13

Place the class I processing pathway in the correct order:

Accepted Answer

A)  Peptides exported from the ER by TAP > peptides are digested by the proteasome > peptides are loaded onto class I > class I is exported to the cell surface
B)  Proteins are digested by the proteasome > peptides are imported into the ER by TAP > peptides are loaded onto MHC class I > class I is exported to the cell surface
C)  MHC class I moves from the cell surface to the lysosome by endocytosis > class I bound peptides are replaced with antigenic peptides in the lysosome > class I returns to the cell surface
D)  Proteins are degraded by TAP > peptides are imported into the lysosome by the proteasome > peptide-MHC class I complexes are exported to the cell surface
E)  MHC class I is transported to the ER by TAP > proteins in the ER are degraded into peptides by the proteasome > peptides bind MHC class I in the ER, and the complex is exported to the cell surface

Question 14

MHC polymorphisms tend to cluster

Accepted Answer

A)  in the peptide-binding groove.
B)  in the transmembrane domain.
C)  in the coreceptor contact residues.
D)  in the framework region.
E)  All of the answers are correct.

Question 15

In your own words, explain how the immune system can activate CD8+ T-cells to eliminate intracellular pathogens (i.e., viruses) unless a dendritic cell happens to become infected.

Accepted Answer

Cross presentation.The process of cross ...

Question 16

Name the primary factor contributing to the observation that human genes found within the MHC locus are inherited as a set, which is described by geneticists as a linkage disequilibrium pattern of inheritance.

Accepted Answer

The individual genes that make up the MH...

Question 17

Which of the following is the BEST example of self-MHC restriction of T cells?

Accepted Answer

A)  A T-cell clone is deleted when it binds too tightly to self-MHC.
B)  A T-cell clone responds more vigorously to a self-peptide than a foreign peptide.
C)  A T-cell clone recognizes foreign MHC.
D)  A T-cell clone only recognizes foreign peptides when presented by self-MHC.
E)  All of the answers are correct.

Question 18

A mutation that renders the MHC class II molecule DM nonfunctional would likely lead to

Accepted Answer

A)  cells with no class II MHC.
B)  cells with no DO.
C)  cells with class II MHC only bound with CLIP.
D)  cells with class II MHC bound with a variety of self-antigens.
E)  a deficiency in CD8+ T cells.

Question 19

Which of the following is an example of cross presentation?

Accepted Answer

A)  An endogenous peptide being presented on MHC class I
B)  An exogenous peptide being presented on MHC class I
C)  An endogenous peptide being presented on MHC class II
D)  An exogenous peptide being presented on MHC class II
E)  A B-cell antigen being presented to a T cell

Exam 7: The Major Histocompatibility Complex and Antigen Presentation

In your own words, explain how the immune system can activate CD8⁺ T-cells to eliminate intracellular pathogens (i.e., viruses) unless a dendritic cell happens to become infected.

Correct Answer
verified
Cross presentation.The process of cross ...
View Answer

T-cell activation can be inhibited by treating antigen-presenting cells with chloroquine.What is chloroquine's mechanism of action?

Correct Answer
verified

Your chances of having the same MHC haplotype as your sibling are

Correct Answer
verified

Which of the following is the BEST example of self-MHC restriction of T cells?

Correct Answer
verified

Which of the following would be the MOST likely source of a peptide bound to an MHC class I molecule?

Correct Answer
verified

How many different MHC classical class I proteins does each nucleated cell in a human heterozygous at the MHC locus express?

Correct Answer
verified

Based on your knowledge of MHC I and II, predict which cell type would be MOST likely not to express detectable MHC I.

Correct Answer
verified

Examine Figure 7-4.(in the text) Can you summarize, in two sentences maximum, what this figure demonstrates about MHC I-peptide antigen interactions?

Correct Answer
verified
The ability of MHC I to bind to a divers...
View Answer

Place the class I processing pathway in the correct order:

Correct Answer
verified

MHC polymorphisms tend to cluster

Correct Answer
verified

One way a developing fetus is protected from attack by the maternal immune system is

Correct Answer
verified

Of the antigen receptors listed here - T-cell receptor, B-cell receptor, MHC I, and MHC II - which would you describe as "promiscuous" in their ligand-binding activity?

Correct Answer
verified
MHC I and MHC II.Any given MHC can bind ...
View Answer

MHC diversity ultimately affects the

Correct Answer
verified

Suppose an individual is deficient in TAP (transporter associated with antigen processing).Is the deficiency MORE likely to produce symptoms of immune deficiency or autoimmunity in the person?

Correct Answer
verified
Both are possible.TAP is impor...
View Answer

Which of the following is an example of cross presentation?

Correct Answer
verified

A mutation that renders the MHC class II molecule DM nonfunctional would likely lead to

Correct Answer
verified

A mutation in which part of a viral protein might allow the virus to evade the adaptive immune response because of its MHC binding?

Correct Answer
verified

Name the primary factor contributing to the observation that human genes found within the MHC locus are inherited as a set, which is described by geneticists as a linkage disequilibrium pattern of inheritance.

Correct Answer
verified
The individual genes that make up the MH...
View Answer

Name an advantage of presenting viral antigens by both the endogenous and exogenous pathways.

Correct Answer
verified
During an active viral infection, typica...
View Answer

Exam 7: The Major Histocompatibility Complex and Antigen Presentation

In your own words, explain how the immune system can activate CD8+ T-cells to eliminate intracellular pathogens (i.e., viruses) unless a dendritic cell happens to become infected.

Correct AnswerverifiedCross presentation.The process of cross ...View AnswerShow Answer

T-cell activation can be inhibited by treating antigen-presenting cells with chloroquine.What is chloroquine's mechanism of action?

Correct AnswerverifiedShow Answer

Your chances of having the same MHC haplotype as your sibling are

Correct AnswerverifiedShow Answer

Which of the following is the BEST example of self-MHC restriction of T cells?

Correct AnswerverifiedShow Answer

Which of the following would be the MOST likely source of a peptide bound to an MHC class I molecule?

Correct AnswerverifiedShow Answer

How many different MHC classical class I proteins does each nucleated cell in a human heterozygous at the MHC locus express?

Correct AnswerverifiedShow Answer

Based on your knowledge of MHC I and II, predict which cell type would be MOST likely not to express detectable MHC I.

Correct AnswerverifiedShow Answer

Examine Figure 7-4.(in the text) Can you summarize, in two sentences maximum, what this figure demonstrates about MHC I-peptide antigen interactions?

Correct AnswerverifiedThe ability of MHC I to bind to a divers...View AnswerShow Answer

Place the class I processing pathway in the correct order:

Correct AnswerverifiedShow Answer

MHC polymorphisms tend to cluster

Correct AnswerverifiedShow Answer

One way a developing fetus is protected from attack by the maternal immune system is

Correct AnswerverifiedShow Answer

Of the antigen receptors listed here - T-cell receptor, B-cell receptor, MHC I, and MHC II - which would you describe as "promiscuous" in their ligand-binding activity?

Correct AnswerverifiedMHC I and MHC II.Any given MHC can bind ...View AnswerShow Answer

MHC diversity ultimately affects the

Correct AnswerverifiedShow Answer

Suppose an individual is deficient in TAP (transporter associated with antigen processing).Is the deficiency MORE likely to produce symptoms of immune deficiency or autoimmunity in the person?

Correct AnswerverifiedBoth are possible.TAP is impor...View AnswerShow Answer

Which of the following is an example of cross presentation?

Correct AnswerverifiedShow Answer

A mutation that renders the MHC class II molecule DM nonfunctional would likely lead to

Correct AnswerverifiedShow Answer

A mutation in which part of a viral protein might allow the virus to evade the adaptive immune response because of its MHC binding?

Correct AnswerverifiedShow Answer

Name the primary factor contributing to the observation that human genes found within the MHC locus are inherited as a set, which is described by geneticists as a linkage disequilibrium pattern of inheritance.

Correct AnswerverifiedThe individual genes that make up the MH...View AnswerShow Answer

Name an advantage of presenting viral antigens by both the endogenous and exogenous pathways.

Correct AnswerverifiedDuring an active viral infection, typica...View AnswerShow Answer

In your own words, explain how the immune system can activate CD8⁺ T-cells to eliminate intracellular pathogens (i.e., viruses) unless a dendritic cell happens to become infected.

Correct Answer
verified
Cross presentation.The process of cross ...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
The ability of MHC I to bind to a divers...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
MHC I and MHC II.Any given MHC can bind ...
View Answer

Correct Answer
verified

Correct Answer
verified
Both are possible.TAP is impor...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
The individual genes that make up the MH...
View Answer

Correct Answer
verified
During an active viral infection, typica...
View Answer