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Describe two mechanisms by which the human nervous system can voluntarily alter the force and velocity of a contraction of the biceps muscle of the arm.

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1. Varying numbers of motor un...

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A muscle produces less force during a twitch than during a tetanic contraction because during a twitch


A) peak cytoplasmic Ca2+ is lower.
B) tropomyosin does not have time to unblock all of the actomyosin binding sites.
C) myosin does not have time to bind to as many actin molecules.
D) the elastic components of the muscle are not fully stretched.

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Mammalian cardiac muscle cells are stimulated to contract by


A) hormonal signals that trigger Ca2+ release and myosin light-chain phosphorylation.
B) electrical signals transmitted through gap junctions from other autorhythmic cardiac muscle cells.
C) action potentials from excitatory autonomic neurons.
D) ion channels that open in response to stretch of the cardiac muscle cell membranes.

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According to the sliding filament theory of muscle contraction, myosin heads pull on _______ filaments and _______.


A) thick; move the Z discs apart
B) thick; move the Z discs together
C) thin; move the Z discs apart
D) thin; move the Z discs together

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Refer to the figure shown. Refer to the figure shown.   Which area(s)  shorten(s)  during muscle contraction? A)  I B)  III C)  I and III D)  III and V Which area(s) shorten(s) during muscle contraction?


A) I
B) III
C) I and III
D) III and V

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Refer to the figure shown. Refer to the figure shown.   In the figure, which numeral represents the A band? A)  I B)  II C)  III D)  IV In the figure, which numeral represents the A band?


A) I
B) II
C) III
D) IV

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How can summation of skeletal muscle twitches occur if the motor neuron's refractory period prevents multiple action potentials from being transmitted to the neuromuscular junction at the same time?


A) The motor neuron's absolute refractory period is much shorter than the time it takes for calcium release and reuptake from the SR.
B) The motor neuron's absolute refractory period is much longer than the time it takes for calcium release and reuptake from the SR.
C) The motor neuron's absolute refractory period is much shorter than the muscle action potential.
D) The motor neuron's absolute refractory period is much longer than the muscle action potential.

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One reason that fast glycolytic muscle fibers fatigue more rapidly than slow oxidative muscle fibers is that fast glycolytic fibers


A) contain lower amounts of ATP than slow oxidative fibers.
B) have a lower capacity for glycolysis than slow oxidative fibers.
C) have a higher capacity for oxidative phosphorylation than slow oxidative fibers.
D) use ATP more rapidly than slow oxidative fibers.

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The small diameter of slow oxidative muscle fibers is particularly advantageous for minimizing the distance over which


A) calcium diffuses from the sarcolemma to the myofibrils.
B) oxygen diffuses from the sarcolemma to the mitochondria.
C) glycogen diffuses from the sarcolemma to the myofibrils.
D) lactate diffuses from the myofibrils to the sarcolemma.

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In striated muscle, _______ before the sarcomere can generate force.


A) Ca2+ must dissociate from troponin C
B) Ca2+ must be pumped by the SR Ca2+-ATPase
C) the SR calcium channel must open
D) calcium must bind to tropomyosin

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During the latent period of an isometric twitch,


A) myosin hydrolyzes ATP and releases from actin.
B) Ca2+ binds to troponin C.
C) ryanodine receptors open and conduct Ca2+ into the SR.
D) tropomyosin moves to block myosin-binding sites on actin.

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Which statement is true of most arthropod and vertebrate skeletal muscle?


A) Muscle fibers are innervated by multiple neurons.
B) Muscle fibers receive both EPSPs and IPSPs.
C) Different myosin isoforms in adjacent fibers produce different maximum shortening velocities.
D) Ca2+ is released from the sarcoplasmic reticulum in response to depolarization of the fiber.

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Why does a skeletal muscle twitch last longer than a skeletal muscle action potential?

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The twitch begins with the action potent...

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Refer to the figure shown. Refer to the figure shown.   In the figure, which panel, taken out of context, represents a state where muscle relaxation could be occurring? A)  I B)  II C)  IV D)  VI In the figure, which panel, taken out of context, represents a state where muscle relaxation could be occurring?


A) I
B) II
C) IV
D) VI

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During an isometric tetanic contraction, the sarcomeres


A) shorten, but the elastic components lengthen.
B) shorten, but the elastic components stay the same length.
C) and the elastic components shorten.
D) lengthen, but the elastic components shorten.

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Refer to the figure shown. Refer to the figure shown.   Which number on the diagram represents the most optimal positioning of actin and myosin before contraction? A)  I B)  II C)  III D)  IV Which number on the diagram represents the most optimal positioning of actin and myosin before contraction?


A) I
B) II
C) III
D) IV

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During an eccentric muscle contraction, the


A) length of the sarcomeres remains unchanged, but the length of the elastic component increases.
B) sarcomeres shorten, but the length of the elastic component remains unchanged.
C) muscle produces force and its length decreases.
D) muscle produces force and its length increases.

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Identify the two major uses of ATP in skeletal muscle cells that are involved in contraction and relaxation and explain why each process uses ATP more rapidly in fast-twitch muscles than in slow-twitch muscles.

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Myosin hydrolyzes ATP as part of the cro...

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In resting skeletal muscle, contraction does not occur because


A) there is very little ATP in the cytoplasm.
B) most of the ATP is bound to other molecules for storage.
C) there is very little calcium in the cytoplasm.
D) myosin is inactivated.

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The diffusion rate of which factor best explains why vertebrates evolved to have slow oxidative muscle fibers that are smaller in diameter than fast glycolytic fibers?


A) Lipid
B) Oxygen
C) Ca2+
D) Glucose

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