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Exam 8: Transmucosal Drug Delivery

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Question 1

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Transcellular drug transport is defined as passage across the intercellular spaces.

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Question 2

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Overall,buccal mucosa is composed of more lipids than sublingual mucosa.

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Which of the following are common characteristics of oral thin films? More than one answer may be correct.

The median turnover time of the buccal mucosa is shorter than that of the sublingual mucosa.

Fill in the blank: ________ are thin flexible strips composed of a drug dissolved/dispersed in a water-dissolving polymer,which hydrates,adheres and quickly dissolves within few seconds when placed in the oral cavity.

Phospholipids can be classified as a non-polar lipid.

Polar lipids located in the intercellular spaces of the buccal/sublingual mucosa are responsible for:

Fill in the blank: An advantage of using liposomal preparations for oral mucosal delivery is that it results in ___________ penetration through the permeability barrier

Solid dosage forms can be classified into quick dissolving and slow dissolving based on their rate of mucosal permeation.

Hydrogels are composed of swellable hydrophilic polymers that swell on contact with saliva in the oral cavity.

Bio-adhesive dosage systems are an effective way of delivering drugs in the oral cavity due to mucin's water holding capacity and ability to adhere to the epithelium.

Buccal mucosa has which of the following? More than one answer may be correct.

Fill in the blank: NovaMist^TM and RapidMist^TM are examples of ________- based buccal drug delivery systems.

Fill in the blank: Quick dissolving drug delivery systems release drug by ????_______ within few seconds to a minute upon contact with saliva.

Fill in the blank: Chewable tablets,sublingual tablets,lollipops and mucoadhesive tablets are examples of ________ dissolving dosage forms.

Fill in the blank: _______ are made of bioadhesive polymers that provide controlled release of drug while adhering to mucosa for long periods of time.

Basement membrane,also known as basal lamina,is a non-cellular structure that separates the epithelium from the connective tissue.

Drug delivery through the oral cavity includes which of the following? More than one answer may be correct.

Fill in the blank: One major goal of mucosal bio-adhesive drug delivery systems is to ______ the retention time in the oral cavity.

The major routes of drug transport across the oral mucosa can be classified as transcellular and paracellular.