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Exam 17: Non-Coding Rnas

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Question 1

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Select possible outcomes after RISC binds to an mRNA during RNA interference. Choose all that apply.

A) Inhibition of translation without mRNA degradation
B) mRNA degradation
C) Movement of the RISC-mRNA complex to a P-body
D) Expulsion of the RISC-mRNA complex from the cell
E) Cell death

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Question 2

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What human disease is associated with mutations in Drosha?

A) Familial amyotrophic lateral sclerosis
B) Alzheimer disease
C) Heart arrhythmias
D) Lung cancer

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Question 3

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Abnormal levels of miRNAs are associated with nearly all forms of what type of human disease?

Select the four most common types of molecules to which ncRNAs bind.

The CRISPR-Cas system in bacteria is most similar to what system in vertebrates?

Ribozymes are RNA molecules with what type of activity?

What is the name of the type of chemical modification on anti-miRNA oligonucleotides used to inhibit miRNA function that involves ribose sugars with an extra bridge connecting the 2' oxygen and the 4' carbon?

SmY RNAs are a family of ncRNAs in nematodes that are thought to be involved in a special type of RNA splicing. Based on this function, SmY RNAs are most likely members of which category of ncRNAs?

In order of their occurrence what are the steps in RNA interference?

You work in a lab that is studying piRISCs and PIWI proteins. You have isolated piRISCs from a cell. What would be one way to identify which piRISCs are involved in cleaving TE RNA vs. those that halt transcription?

With which injection did Mello and Fire observe the lowest amount of mex-3 probe staining?

Select the ways in which modifications to the chromatin brought about by HOTAIR and associated proteins are proposed to inhibit transcription.

You are working in a lab that studies snoRNAs. You mutate the antisense sequences in a C/D box snoRNA to completely different sequences. What results do you expect compared to wild type snoRNA? Check all that apply.

Select functions that ncRNAs can perform. Choose all that apply.

You are working in a lab that studies ncRNAs. You develop an assay to isolate ncRNAs and any associated molecules. You must then identify the molecules you have isolated. You find a molecule that is associated with an ncRNA that is not changed by protease, RNase, or DNase. The associated molecule is most likely

In an in vitro translation assay radioactive amino acids can be incorporated into proteins and the proteins separated from the unincorporated amino acids (higher counts per minute indicates more protein synthesis) . Given the following data what are the conclusions that you would come to?

Select the features that made protobionts possible precursors of living cells.

Select the ncRNA that facilitates the binding of telomerase to the telomere and acts as a template for DNA replication.

The ncRNA HOTAIR recruits what type of proteins to target genes?

Into which gene of the CRISPR-Cas system are fragments of bacteriophage DNA inserted?