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A recessive allele on the X chromosome is responsible for red-green color blindness in humans. A woman with normal vision whose father is color blind marries a color-blind male. What is the probability that this couple's first son will be color blind?


A) 1/4
B) 1/2
C) 2/3
D) 3/4

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Why are males more often affected by sex-linked traits than females?


A) Male hormones such as testosterone often alter the effects of mutations on the X chromosome.
B) Female hormones such as estrogen often compensate for the effects of mutations on the X chromosome.
C) X chromosomes in males generally have more mutations than X chromosomes in females.
D) Males are hemizygous for the X chromosome.

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Which of the following is an example of monosomy in humans?


A) Turner syndrome
B) Klinefelter syndrome
C) Down syndrome
D) trisomy X

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Which of the following correctly describes a Philadelphia chromosome?


A) a human chromosome 22 that has had a specific translocation
B) a human chromosome 9 that is found only in one type of cancer
C) an animal chromosome found primarily in the mid-Atlantic area of the United States
D) a chromosome found only in mitochondria

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Genomic imprinting is generally due to the addition of methyl (-CH₃) groups to C nucleotides and chemical histone changes to silence a given gene. If this depends on the sex of the parent who transmits the gene, which of the following statements must be true?


A) Genes required for early development stages must not be imprinted.
B) Methylation of this kind must occur more in males than in females.
C) Methylation must be reversible in ovarian and testicular cells.
D) The imprints are transmitted only to gamete-producing cells.

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Cinnabar eye color is a sex-linked, recessive characteristic in fruit flies. If a female having cinnabar eyes is crossed with a wild-type male, what percentage of the F₁ males will have cinnabar eyes?


A) 0%
B) 25%
C) 50%
D) 100%

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During meiosis, a defect occurs in a cell that results in the failure of spindle microtubules binding at the kinetochores. Which of the following statements describes the most likely result of such a defect?


A) New microtubules with more effective binding capabilities to kinetochores will be synthesized to compensate for the defect.
B) Excessive cell divisions will occur resulting in cancerous tumors and an increase in the chromosome numbers known as polyploidy.
C) The defect will be bypassed in order to ensure normal chromosome distribution in the new cells.
D) The resulting cells will not receive the correct number of chromosomes in the gametes, a condition known as aneuploidy.

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Use the following information to answer the question.  Sex  Phenotype  Number  male  wild 123 male  yellow 116 female  wild 240\begin{array} { c c c } \text { Sex } & \text { Phenotype } & \text { Number } \\\text { male } & \text { wild } & 123 \\\text { male } & \text { yellow } & 116 \\\text { female } & \text { wild } & 240\end{array} In a Drosophila experiment, a cross was made between homozygous wild-type females and yellow-bodied males. All of the resulting F?s were phenotypically wild type. However, adult flies of the F? generation (resulting from matings of the F?s) had the characteristics shown in the figure. How is the mutant allele for yellow body inherited?


A) It is not X-linked.
B) It is X-linked.
C) It is inherited by X inactivation.
D) It is Y-linked.

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A man who is a dwarf with achondroplasia and normal vision marries a color-blind woman of normal height. The man's father was six feet tall, and both the woman's parents were of average height. Dwarfism caused by achondroplasia is autosomal dominant, and red-green color blindness is X-linked recessive. What proportion of their sons would be color blind and of normal height?


A) none
B) half
C) one out of four
D) all

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Use the following information to answer the question. A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots due to an allele (c) of gene C. The three genes are linked and recombine. A geneticist performed a testcross with an organism that had been found to be heterozygous for the three recessive traits, and she was able to identify progeny of the following phenotypic distribution (+ = wild type) :  Phenotypes  Leaves  Stems  Roots  Number 1a++142a+c03ab+324abc4405+b+06+bc167++c288+++470 Total 1000\begin{array} { | l | l | l | l | l | } \hline \text { Phenotypes } & \text { Leaves } & \text { Stems } & { \text { Roots } } & { \text { Number } } \\\hline1 & a & + & + & 14 \\\hline 2 & a & + & c & 0 \\\hline 3 & a & b & + & 32 \\\hline 4 & a & b & c & 440 \\\hline 5 & + & b & + & 0 \\\hline 6 & + & b & c & 16 \\\hline 7 & + & + & c & 28 \\\hline 8 & + & + & + & 470 \\\hline &&& \text { Total } & 1000 \\\hline\end{array} If recombination frequency is equal to distance in map units, what is the approximate distance between genes A and B?


A) 3 map units
B) 6 map units
C) 15 map units
D) 30 map units

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Use the following information to answer the question.  Sex  Phenotype  Number  male  wild 123 male  yellow 116 female  wild 240\begin{array} { c c c } \text { Sex } & \text { Phenotype } & \text { Number } \\\text { male } & \text { wild } & 123 \\\text { male } & \text { yellow } & 116 \\\text { female } & \text { wild } & 240\end{array} In a Drosophila experiment, a cross was made between homozygous wild-type females and yellow-bodied males. All of the resulting F?s were phenotypically wild type. However, adult flies of the F? generation (resulting from matings of the F?s) had the characteristics shown in the figure. How is the mutant allele for yellow body inherited?


A) It is recessive.
B) It is codominant.
C) It is dominant.
D) It is incompletely dominant.

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When Thomas Hunt Morgan crossed his red-eyed F₁ generation flies to each other, the F₂ generation included both red- and white-eyed flies. Remarkably, all the white-eyed flies were male. What was the explanation for this result?


A) The gene involved is located on the Y chromosome.
B) The gene involved is located on the X chromosome.
C) The gene involved is located on an autosome, but only in males.
D) Other male-specific factors influence eye color in flies.

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Which of the following statements would explain a testcross involving F₁ dihybrid flies in which more parental-type offspring than recombinant-type offspring are produced?


A) The two genes are closely linked on the same chromosome.
B) The two genes are linked but on different chromosomes.
C) Recombination did not occur in the cell during meiosis.
D) Both of the characters are controlled by more than one gene.

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Use the following information to answer the question. A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots due to an allele (c) of gene C. The three genes are linked and recombine. A geneticist performed a testcross with an organism that had been found to be heterozygous for the three recessive traits, and she was able to identify progeny of the following phenotypic distribution (+ = wild type) :  Phenotypes  Leaves  Stems  Roots  Number 1a++142a+c03ab+324abc4405+b+06+bc167++c288+++470 Total 1000\begin{array} { | l | l | l | l | l | } \hline \text { Phenotypes } & \text { Leaves } & \text { Stems } & { \text { Roots } } & { \text { Number } } \\\hline 1 & a & + & + & 14 \\\hline 2 & a & + & c & 0 \\\hline 3 & a & b & + & 32 \\\hline 4 & a & b & c & 440 \\\hline 5 & + & b & + & 0 \\\hline 6 & + & b & c & 16 \\\hline 7 & + & + & c & 28 \\\hline 8 & + & + & + & 470 \\\hline & & & \text { Total } & 1000 \\\hline\end{array} Which of the following are the phenotypes of the parents in this cross?


A) 2 and 5
B) 1 and 6
C) 4 and 8
D) 3 and 7

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Which of the following phrases correctly defines what one map unit is?


A) the physical distance between two linked genes
B) a 1% frequency of recombination between two genes
C) 1 nanometer of distance between two genes
D) the recombination frequency between two genes assorting independently

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The SRY gene is best described as ________.


A) a gene present on the X chromosome that triggers female development
B) an autosomal gene that is required for the expression of genes on the Y chromosome
C) a gene present on the Y chromosome that triggers male development
D) an autosomal gene that is required for the expression of genes on the X chromosome

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Use the following information to answer the question. A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots due to an allele (c) of gene C. The three genes are linked and recombine. A geneticist performed a testcross with an organism that had been found to be heterozygous for the three recessive traits, and she was able to identify progeny of the following phenotypic distribution (+ = wild type) :  Phenotypes  Leaves  Stems  Roots  Number 1a++142a+c03ab+324abc4405+b+06+bc167++c288+++470 Total 1000\begin{array} { | l | l | l | l | l | } \hline \text { Phenotypes } & \text { Leaves } & \text { Stems } & { \text { Roots } } &{ \text { Number } } \\\hline 1 & a & + & + & 14 \\\hline 2 & a & + & c & 0 \\\hline 3 & a & b & + & 32 \\\hline 4 & a & b & c & 440 \\\hline 5 & + & b & + & 0 \\\hline 6 & + & b & c & 16 \\\hline 7 & + & + & c & 28 \\\hline 8 & + & + & + & 470 \\\hline & & & \text { Total } & 1000 \\\hline\end{array} The greatest distance among the three genes is between a and c. What does this mean?


A) Gene c is between a and b.
B) Genes are in the order: a-b-c.
C) Gene a is not recombining with c.
D) Gene a is between b and c.

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Use the following figure to answer the question. Use the following figure to answer the question.   The pedigree in the figure shows the transmission of a trait in a particular family. Based on this pattern of transmission, the trait is most likely ________. A)  mitochondrial B)  sex-linked dominant C)  sex-linked recessive D)  autosomal dominant The pedigree in the figure shows the transmission of a trait in a particular family. Based on this pattern of transmission, the trait is most likely ________.


A) mitochondrial
B) sex-linked dominant
C) sex-linked recessive
D) autosomal dominant

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Mitochondrial DNA is primarily involved in coding for proteins needed for protein complexes of the electron transport chain and ATP synthase. Therefore, mutations in mitochondrial genes would most affect which of the following processes?


A) DNA synthesis in cells of the immune system
B) the movement of oxygen into erythrocytes
C) generation of ATP in muscle cells
D) the storage of urine in the urinary bladder

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A phenotypically normal prospective couple seeks genetic counseling because the man knows that he has a translocation of a portion of his chromosome 4, which has been exchanged with a portion of his chromosome 12. Although his translocation is balanced, he and his wife want to know the probability that his sperm will be abnormal. What is your prognosis regarding his sperm?


A) One-quarter will carry the two normal chromosomes, 4 and 12, one-quarter will have only the two translocation chromosomes and no normal chromosomes 4 and 12, and half will have one normal and one translocated chromosome.
B) All will carry the same translocation as the father.
C) None will carry the translocation.
D) Half will be normal, and the rest will have the father's translocation.

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