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Anionic proteins and phosphates have little influence over the resting membrane potential (RMP) because


A) they are found in roughly equal concentrations across the membrane
B) they are negatively charged, and the rmp relies on positive charges
C) they are bound to cations and thus can't cross the membrane
D) they do not have leak channels and thus can't cross the membrane

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Summation of postsynaptic potentials determines whether or not an action potential will be generated at the axon hillock. The final amplitude of the summed potentials is dependent upon


A) distance the post-synaptic potential has traveled
B) the polarity of the potential (epsp or ipsp)
C) the timing of the potential (did they arrive close enough together to be summed)
D) All of the choices will affect the final amplitude.

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An investigator is trying to slow the rate of infection of neurons by the herpes simplex virus. Which of these proteins in the neuron could she target to prevent the virus from reaching the cell body where it could replicate?


A) dynein
B) kinesin
C) microtubules
D) dynein and microtubules

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Saltatory conduction is different from continuous conduction because it


A) occurs in axons with myelin on them
B) occurs in dendrites
C) is slower than continuous conduction
D) utilizes more energy than continuous conduction

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In a dendroaxonic synapse the part of the postsynaptic cell receiving the signal is the


A) dendrite
B) cell body
C) axon
D) myelin

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A cell with leak channels that are only permeable to Cl- has been placed in a petri dish. Which of the following statements accurately describes the relationship between the concentration gradient and the Cl- equilibrium potential (ECl) ?


A) A higher concentration of Cl- outside the cell will create a positive equilibrium potential.
B) A higher concentration of Cl- inside the cell will create a positive equilibrium potential.
C) A higher concentration of Cl- inside the cell will create a negative equilibrium potential.
D) It does not matter what the initial concentration is because Cl- will always reach a negative equilibrium potential.

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Speed of conduction of action potentials along an axon is increased in


A) axons with a larger diameter
B) axons that are myelinated
C) axons with more axon collaterals
D) axons with both myelin and a larger diameter

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How can one tell if action potentials are generated by a threshold or suprathreshold stimuli?


A) the suprathreshold will have the largest amplitude
B) threshold stimuli will not always produce an action potential
C) the suprathreshold stimulus will create a higher frequency of action potentials
D) there in no difference in action potentials generated by either type of stimulus

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Which of the following is NOT a type of graded potential?


A) post-synaptic potential
B) receptor potential
C) end plate potential
D) resting membrane potential

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The doctor taps your leg just below your knee to test your reflexes. Your leg swings out at about the same time you perceive that your leg was tapped because of a


A) diverging circuit
B) converging circuit
C) reverberating circuit
D) parallel after-discharge circuit

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Retrograde and anterograde transport occur in the


A) axon
B) dendrites
C) cell body (soma)
D) axon hillock

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How does increasing the extracellular calcium concentration lead to a decrease in excitability?


A) Ca2+ can block Na+ channels, so the extra concentration means fewer channels are available for Na+ to move through.
B) Ca2+ increases the voltage threshold required to open the Na+ channels, so the extra concentration means channels require more stimulus.
C) Ca2+ decreases the voltage threshold required to open the K+ channels, so the extra concentration means K+ channels will open sooner, hyperpolarizing the cell.
D) It makes the outside of the cell more positive, so by comparison the inside is more negative and therefore less likely to depolarize.

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The resting membrane potential is a measure of charge difference across the unstimulated cell membrane. This charge difference can exist because


A) the membrane is permeable to all substances
B) the membrane has channels that serve as conductors
C) the membrane has lipid components that serve as an insulator
D) the membrane is permeable to all substances because of its channels

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A surgeon is repairing damage to an individual's abdominal area, and accidentally connects a nerve that originally controlled the smooth muscle of the GI tract to the skeletal muscle of the abdominal wall. Hypothesize what might happen in this instance.


A) The individual will no longer have voluntary control of the smooth muscle in his GI tract.
B) The nerve will change divisions and contain only somatic neurons.
C) Nothing, because the tissue of the GI tract responds only to the enteric nervous system, and the autonomic innervation was not vital.
D) This area of the GI tract will no longer be able to exchange information with the CNS through this nerve.

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Assume the potentials from the following combinations of dendrites reach the axon hillock/trigger zone at the same time. Which combination will have the greatest chance of generating an action potential? Assume the potentials from the following combinations of dendrites reach the axon hillock/trigger zone at the same time. Which combination will have the greatest chance of generating an action potential?   A)  1, 2, 4 B)  2, 3, 4 C)  3, 4, 5 D)  1, 4, 5


A) 1, 2, 4
B) 2, 3, 4
C) 3, 4, 5
D) 1, 4, 5

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In the synaptic end bulb, the action potential leads to the release of neurotransmitter. What links these two types of signals?


A) The action potential triggers voltage-gated Na+ channels to open and the depolarization causes the vesicle walls to merge with the membrane.
B) The action potential causes a change in the proteins on the vesicle membranes such that the vesicle binds to the cell membrane and begins exocytosis.
C) The action potential triggers voltage-gated Ca2+ channels to open and the Ca2+ that flows in starts a cascade of protein reactions that allows exocytosis of the neurotransmitters.
D) The action potential causes K+ to leave during repolarization and the decrease in K+ concentration triggers vesicles to bind to the membrane, releasing their contents.

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You are working with some new neural cells and accidentally spill a few drops of a chemical solution into the petri dish. Shortly afterwards, you notice an increase in graded potentials in the cells. You hypothesize that the channels responsible for these graded potentials are


A) ligand-gated
B) leak channels
C) mechanically-gated
D) voltage-gated

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A major function of the nervous system is communication that allows our bodies to maintain homeostasis. In many cases reflexes will occur without our awareness. Which function of the nervous system is bypassed in this case?


A) sensory function
B) motor function
C) integrative function
D) none; all functions occur in reflexes

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An individual touches a sharp object and cries out in pain, but is unable to pull her hand away from the object. In this situation, the _________ neurons are the most likely reason she cannot respond.


A) sensory neurons
B) sympathetic neurons
C) parasympathetic neurons
D) somatic neurons

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A scientist discovers that a neuron does not have adequate stores of neurotransmitter. What part of the neuron is he observing?


A) the axon
B) the synaptic end bulbs
C) the dendrites
D) the cell body

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