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What is the limitation that shifts the predominant use of fat for energy at low-intensity exercise to the predominant use of carbohydrate oxidation at high-intensity exercise?


A) rate of production of ATP
B) rate of mobilization of fatty acids from the adipocytes
C) rate of transamination of amino acids
D) rate of muscle glycogen breakdown

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During exercise, which of the following contributes only minimally to the amount of ATP used by working muscles?


A) muscle glycogen
B) blood glucose
C) plasma fatty acids
D) oxidation of amino acids

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Which amino acid produced by transamination of pyruvate with glutamic acid provides a disposal route for nitrogen produced from the catabolism of muscle amino acids?


A) histidine
B) tyrosine
C) tryptophan
D) alanine

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Amino acids from muscle breakdown provide the chief substrate for which metabolic process?


A) glycolysis
B) gluconeogenesis
C) glycogenesis
D) pentose phosphate pathway

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What is the final common catabolic pathway for metabolism of carbohydrate, protein, and fat?


A) acetyl-CoA; oxidation
B) gluconeogenesis; glycolysis
C) Krebs cycle; electron transport
D) lipolysis; ketogenesis

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Under the influence of insulin, which of the following pathways is increased?


A) glycogenesis
B) glycogenolysis
C) phosphorylation of glycogen synthase
D) phosphorylation of glycogen phosphorylase

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A

What amino acid plays an important role in controlling toxicity from ammonia released during amino acid catabolism by the glutamate dehydrogenase reaction?


A) glutamine
B) glycine
C) serine
D) valine

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In the human, most triacylglyerols are synthesized by the


A) adipose tissue.
B) heart.
C) liver.
D) brain.

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In the fasted state, you would find:


A) dephosphorylated glycogen synthase.
B) an increase in the amount of hexokinase.
C) allosteric inhibition of phosphofructokinase by NAD.
D) induction of pyruvate carboxylase.
E) more than one of the above

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What intermediate's formation in the Krebs cycle is interrelated with the biosynthesis of heme?


A) succinyl-CoA
B) oxaloacetate
C) citrate
D) fumarate

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In which organ does urea synthesis occur?


A) kidney
B) spleen
C) liver
D) pancreas

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What is the preferred source of energy used by muscles to spare protein during prolonged starvation?


A) ketones
B) glucose
C) fatty acids
D) amino acids

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A

How long does it take for the postabsorptive state to evolve into the fasting state?


A) 12-18 hours
B) 24-36 hours
C) 18-48 hours
D) 36-72 hours

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After three days of starvation, what proportion of the energy needs of the brain is supplied by ketones?


A) one-eighth
B) one-fourth
C) one-third
D) one-half

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Which amino acid is considered purely ketogenic?


A) methionine
B) histidine
C) tryptophan
D) leucine

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Training enhances utilization of fat as the primary energy substrate during submaximal exercise due to


A) enhanced activity of glycolytic enzymes.
B) enhanced activity of mitochondrial oxidative enzymes.
C) enhanced glucose uptake.
D) decreased carnitine acyltransferase.

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B

Which of the following amino acids is glucogenic in the post-absorptive state?


A) taurine
B) leucine
C) alanine
D) lysine

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A protein-sparing shift in metabolism from gluconeogenesis to lipolysis occurs during the


A) early fasting state.
B) fasting state.
C) starvation state.
D) fed state.

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Which of the following actions of insulin occurs only after hours or days?


A) membrane changes for glucose transport
B) inhibition of activity of catabolic enzymes
C) repression of synthesis of catabolic enzymes
D) promotion of cell replication

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Which of the following is NOT transported by the vascular system?


A) regulatory hormonal messages from the endocrine system
B) oxygen from the respiratory system
C) regulatory neural messages from the nervous system
D) organic nutrients and minerals from the digestive system

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