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A 48- hour old infant is brought to the clinic with signs of severe bacterial conjunctivitis (infection of the eye) . The infant was born at home, with the birth assisted only by an unlicensed midwife, and no pharmaceutical interventions performed on the mother or infant. Which infectious agents is the likely culprit?


A) Chlamydia trachomatis
B) HSV- 2
C) bacterial vaginosis due to mixed anaerobic species
D) Neisseria gonorrhoeae
E) Neither Chlamydia trachomatis nor Neisseria gonorrhoeae should be ruled out without further testing.

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Urinary catheters pose risks of causing urinary tract infections because


A) they block urine flow out of the bladder.
B) they block urine flow out of the bladder and they can introduce bacteria from the skin, anal, or external genital areas into the bladder.
C) they can introduce bacteria from the skin, anal, or external genital areas into the bladder.
D) they provide a surface for bacterial biofilms to establish and they can introduce bacteria from the skin, anal, or external genital areas into the bladder.
E) they provide a surface for bacterial biofilms to establish.

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Infection in the urinary tract is limited by all the following except


A) the urinary microbiome.
B) the slightly acidic pH of urine.
C) constriction of the urethra by the prostate gland in men and the placement of the urethra near the anus in women.
D) the flushing action of urine through the ureters and urethra.
E) constriction of the urethra by the prostate gland in men.

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Which is not an innate protection of the female reproductive tract?


A) Normal microbiome members generate products which prevent pathogen growth.
B) The vaginal lining contains ciliate cells which trap and expel bacteria from the tract.
C) The vaginal lining sheds its cells every few hours.
D) Lysozyme and antimicrobial peptides are present in vaginal secretions.
E) Mucous secretions trap microbes.

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Compared to complicated urinary tract infections (UTIs) , uncomplicated UTIs are less likely to


A) recur after initial treatment.
B) involve a bacterial infection.
C) be diagnosed in women rather than men.
D) respond to antibiotic therapy.
E) be diagnosed in otherwise healthy individuals.

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No bacteria have been detected in the semen of healthy men.

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TORCH pathogens are all characterized by


A) transmission through sexual contact and the ability to cause intrauterine infections.
B) the ability to cause intrauterine infections which are linked to infertility.
C) the ability to cross the placenta to infect a developing fetus.
D) transmission through sexual contact, the ability to cause intrauterine infections which are linked to infertility, and the ability to cross the placenta to infect a developing fetus.
E) transmission through sexual contact.

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A urine dipstick test is negative for elevated nitrite, but bacteriological culturing reveals Gram- positive cocci. Uropathogenic Escherichia coli is indicated.

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Chlamydia may result in any of the following except


A) pelvic pain with fever in women.
B) pelvic inflammatory disease in women.
C) neonatal conjunctivitis.
D) severe neurological disorders such as seizures, vertigo, memory and sensory impairment, and paralysis.
E) urethritis in males.

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Men, rather than women, make up the majority of syphilis cases.

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Lymphogranuloma venereum differs from the infection caused by the trachoma biovar of Chlamydia trachomatis in that


A) lymphogranuloma venereum may result in the formation of buboes and tissues necrosis.
B) lymphogranuloma venereum bacteria do not have an intracellular lifestyle.
C) lymphogranuloma venereum is not sexually transmitted.
D) lymphogranuloma venereum is not treatable with antibiotics such as doxycycline.
E) lymphogranuloma venereum is not treatable with antibiotics such as doxycycline and is not sexually transmitted.

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Unlike many other STIs, chanchroid is often symptomatic with resulting in quick treatment as patients actively seek medical attention.


A) painful lesions, disseminated body- wide rash, and high fever
B) painful lesions
C) disseminated body- wide rash
D) painful lesions and disseminated body- wide rash
E) high fever

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A vaginal swab examined under the microscope reveals the presence of clue cells. Bacterial vaginosis is likely indicated.

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Trichomoniasis is characterized by


A) many asymptomatic infections.
B) the need for long- term antibiotic therapy to result in a cure.
C) dysbiosis of the microbiome.
D) non- motile pathogen that forms persistent biofilms.
E) structural morphogenesis linked to pathology.

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Which of the following would be observed as a result of vulvovaginal candidiasis?


A) clue cells
B) a "cottage cheese" discharge
C) pus- filled lesions
D) clue cells and a "cottage cheese" discharge
E) pus- filled lesions and a "cottage cheese" discharge

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Which is the true statement about vaginosis and vaginitis?


A) The two conditions are always mutually exclusive.
B) Vaginitis is always due to microbiome dysbiosis.
C) Vaginosis is not likely to be sexually transmitted.
D) Vaginitis describes vaginal inflammation while vaginosis does not.
E) The two conditions are always seen together.

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Despite the approval of several vaccines against human papilloma virus since 2006, infection rates of HPV in young women have not declined.

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The more dangerous CNS and disseminated forms can be minimized through which of the following interventions?


A) administration of antiviral drugs to the affected newborn and delivery by cesarean section
B) administration of antiviral drugs to the affected newborn
C) vaccination of pregnant women
D) delivery by cesarean section and vaccination of pregnant women
E) delivery by cesarean section

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Which statement is not true about the urinary microbiome?


A) The most consistently detected species are Lactobacillus and Streptococcus.
B) Most species can be cultivated using standard laboratory techniques.
C) Shifts in microbiome composition may be associated with physiological concerns such as incontinence.
D) The healthy urinary tract was believed to be sterile until molecular methods of analysis became available.
E) The species composition is consistent throughout the urinary system, across the lifespan or from person to person.

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A urine dipstick test can diagnose urinary tract infections by indicating


A) conversion of nitrite to nitrate in the urine.
B) elevated levels of leukocyte esterase.
C) the presence of glucose in the urine.
D) direct detection of Gram- positive or Gram- negative bacteria.
E) elevated creatine and BUN levels.

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