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Which of the following accurately describes the thick ascending limb of the loop of Henle?


A) permeable to water and does NOT contain Na+/K+/Cl- cotransporters
B) permeable to water and contains Na+/K+/Cl- cotransporters
C) permeable to water in the presence of specific hormones
D) impermeable to water and does NOT contain Na+/K+/Cl- cotransporters
E) impermeable to water and contains Na+/K+/Cl- cotransporters

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A substance is in negative balance when


A) its usage by cells is decreased.
B) it enters plasma at a greater rate than it exits plasma.
C) its production by cells is increased.
D) it exits plasma at a greater rate than it enters plasma.
E) it enters plasma at the same rate it exits plasma.

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Consumption of salty foods without drinking water will increase plasma osmolarity and cause cells to shrink.

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What regulates the rate of water loss?


A) lungs
B) kidney
C) skin
D) digestive tract
E) cardiovascular system

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A substance is in positive balance when


A) it exits plasma at a greater rate than it enters plasma.
B) it enters plasma at the same rate it exits plasma.
C) its production by cells is decreased.
D) its usage by cells is increased.
E) it enters plasma at a greater rate than it exits plasma.

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How does severe vomiting cause a metabolic alkalosis?


A) loss of phosphate
B) production of hydrogen ions
C) loss of hydrogen ions
D) production of bicarbonate
E) loss of bicarbonate

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Plasma can gain solutes and/or water from which of the following?


A) gastrointestinal tract only
B) renal tubules only
C) bone only
D) both the gastrointestinal tract and bone
E) both the gastrointestinal tract and renal tubules

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Aldosterone is released from the in response to _ .


A) adrenal cortex : increases in plasma potassium
B) posterior pituitary : increases in plasma osmolarity
C) macula densa : increased flow of tubular fluid in the distal tubule
D) adrenal medulla : decreases in plasma sodium
E) pancreas : increases in plasma glucose

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The obligatory water loss refers to the lowest volume of urine that must be produced to eliminate solutes.

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What hormone decreases calcium levels in blood?


A) calcitonin
B) parathyroid hormone
C) ADH
D) angiotensin II
E) aldosterone

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Aquaporin- 3 is located on what membrane in the absence of ADH?


A) proximal tubule basolateral membrane
B) principal cells apical membrane
C) intercalated cells basolateral membrane
D) proximal tubule apical membrane
E) principal cells basolateral membrane

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What solute maintains the medullary interstitial fluid osmotic gradient?


A) sodium ions
B) urea
C) water
D) glucose
E) potassium ions

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Seawater has an osmolarity of around 1000 mOsm, mostly from dissolved sodium. Given what you know about the osmolarity in most of the cells in the body, why is it dangerous to drink seawater?


A) In the nervous system, the additional extracellular sodium concentration would slow down the normal flow of sodium ions used to generate action potentials.
B) In the digestive system, the seawater would draw more water out of the bloodstream than would be absorbed, leading to severe dehydration.
C) In the cardiovascular system, the higher sodium levels would decrease the pressure in the arteries making it more difficult to get blood to the systemic capillaries.
D) In membrane transport, the increased sodium concentration would slow down secondary active transport of glucose into cells.
E) In the renal system, the osmolarity of the medulla of the kidney would become even more concentrated.

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What hormone stimulates the release of aldosterone?


A) ADH
B) aldosterone
C) angiotensin II
D) atrial natriuretic peptide
E) parathyroid hormone

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As the body becomes dehydrated, the osmolarity of the body fluids decreases.

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Which of the following is NOT a response to hemorrhage?


A) increased epinephrine secretion
B) decreased renin secretion
C) increased ADH release
D) increased angiotensin II production
E) increased sympathetic activity

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If hydrogen ions are added to a solution, the pH will


A) increase.
B) decrease.
C) remain the same.

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The bone can supply calcium to the plasma by what process?


A) ossification
B) filtration
C) resorption
D) reabsorption
E) calcification

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A decrease in plasma calcium will initiate an increase in the release of which of the following?


A) parathyroid hormone only
B) calcitonin only
C) 1,25- dihydroxy vitamin D3 only
D) both parathyroid hormone and calcitonin
E) both parathyroid hormone and 1,25- dihydroxy vitamin D3

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When an increase in hydrogen ions remains after one hour, this will lead to a(n)


A) increased hydrogen reabsorption in the kidneys.
B) increase in hydrogen ion secretion from the kidneys.
C) decrease in bicarbonate reabsorption in the kidneys.
D) failure of the kidneys to filter any more hydrogen ions.
E) increase in bicarbonate secretion in the kidneys.

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