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What enzyme converts angiotensin I into angiotensin II?


A) renin
B) angiotensin converting enzyme (ACE)
C) atrial natriuretic peptide
D) carbonic anhydrase
E) mucin

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What stimulates atrial natriuretic peptide release?


A) changes in the concentration of sodium in the blood of the atrium
B) renin
C) changes in the concentration of potassium in the blood of the atrium
D) distension of the atrial wall due to an increase in plasma volume
E) distension of the atrial wall due to an increase in blood pressure

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Which of the following diseases is associated with decreased responsiveness of the renal tubules to ADH?


A) diabetes mellitus type 1
B) diabetes mellitus type 2
C) diabetic nephropathy
D) nephrogenic diabetes insipidus
E) central diabetes insipidus

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Which of the following conditions triggers the release of renin?


A) high blood pressure
B) low blood pressure
C) increased sympathetic stimulation
D) atrial stretching due to increased plasma volume
E) increased mean arterial pressure (MAP)

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In both the proximal and distal tubules, the reabsorption of sodium involves the active transport of sodium across the basolateral membrane.

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Which statement BEST distinguishes metabolic acidosis from respiratory acidosis?


A) Metabolic acidosis is a disturbance in blood pH caused by exercise as opposed to hyper -or hypoventilation.
B) Metabolic acidosis occurs due to changes in PO2 as opposed to PCO2.
C) Metabolic acidosis occurs due to changes in bicarbonate as opposed to PCO2.
D) Metabolic acidosis occurs due to changes in blood glucose as opposed to changes in PO2 and PCO2.
E) Metabolic acidosis is a disturbance in blood pH caused by something other than an abnormal PCO2.

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Under severe acidic conditions, the proximal tubules can convert________into bicarbonate.


A) glutamate
B) glycine
C) glutamine
D) carbon monoxide
E) lysine

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The activity of the respiratory system can increase pH by


A) a hypoventilation -induced increase in PCO2.
B) a hyperventilation -induced decrease in PCO2.
C) a hyperventilation -induced increase in PCO2.
D) a hypoventilation -induced decrease in PCO2.
E) increasing the amount of carbonic acid in the blood.

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Kidneys compensate for changes in plasma volume and osmolarity by adjusting the rate of water


A) reabsorption only.
B) secretion only.
C) resorption only.
D) reabsorption and secretion.
E) secretion and resorption.

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If nothing else is removed from the filtrate once it reaches the late distal tubules, the urine excreted would have which of the following properties?


A) low osmolarity and low volume
B) high osmolarity and low volume
C) devoid of ions and large volume
D) low osmolarity and large volume
E) high osmolarity and large volume

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ADH increases the insertion of aquaporin -2 where?


A) proximal tubule basolateral membrane
B) intercalated cells basolateral membrane
C) principal cells apical membrane
D) principal cells basolateral membrane
E) proximal tubule apical membrane

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In a state of negative balance, the quantity of a substance in the plasma tends to increase.

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How might a high -protein diet cause metabolic acidosis?


A) loss of hydrogen ions
B) direct production of hydrogen ions
C) loss of phosphate
D) loss of bicarbonate
E) production of phosphoric acid and sulfuric acid

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In comparison with the renal cortex, fluid in the proximal tubule is hyperosmotic.

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Renal compensation is the final mechanism for the reversal of pH change within the body. Describe the mechanisms that underlie renal compensation, including the proteins involved in hydrogen and bicarbonate transport within the proximal and distal tubules. Include mechanisms for synthesis of new bicarbonate.

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In the proximal tubules, bicarbonate rea...

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Changes in acid -base balance are continuously occurring. The body must adjust to those changes through three mechanisms that differ in their ability to affect pH and in their time courses. Describe the three mechanisms that respond to changes in blood pH and their temporal course.

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The first line of defense against a chan...

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Receptors for ADH are located where?


A) principal cells basolateral membrane
B) proximal tubule apical membrane
C) principal cells apical membrane
D) intercalated cells basolateral membrane
E) proximal tubule basolateral membrane

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The primary function of atrial natriuretic peptide (ANP) is to


A) increase potassium secretion thereby decreasing potassium reabsorption.
B) increase sodium secretion thereby decreasing sodium reabsorption.
C) decrease potassium secretion thereby increasing potassium reabsorption.
D) increase the stretching capacity of the atria.
E) decrease sodium secretion thereby increasing sodium reabsorption.

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A patient is exhibiting several signs of acid -base imbalance. Blood tests reveal that blood pH is 7.5, and bicarbonate and carbon dioxide levels in blood are both low. What is the state of this patient?


A) metabolic alkalosis with respiratory compensation
B) respiratory alkalosis with renal compensation
C) respiratory acidosis with renal compensation
D) metabolic acidosis with respiratory compensation
E) Blood pH is normal.

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How does severe diarrhea cause a metabolic acidosis?


A) loss of phosphate
B) production of bicarbonate
C) loss of bicarbonate
D) loss of hydrogen ions
E) production of hydrogen ions

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