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What explains the dramatic acceleration in lengthwise bone growth at puberty?


A) Increased activity of osteoclasts occurs in response to parathyroid hormone stimulation.
B) Increased rate of calcium deposition occurs due to high blood calcium levels.
C) Increased physical activity causes lengthwise growth in response to bone stress.
D) Increased secretion of sex hormones promotes epiphyseal plate growth.
E) Increased absorption of dietary vitamins and minerals strengthens the matrix.

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Parathyroid hormone release is triggered by ________ levels of calcium in the blood.


A) high
B) low

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Bone growth in which the bone increases in diameter is called


A) interstitial growth.
B) epiphyseal growth.
C) appositional growth.
D) endosteal growth.
E) cancellous bone growth.

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As the bone matrix calcifies and the secreting cells become walled in,


A) osteoblasts become osteocytes.
B) osteogenic progenitors become osteoclasts.
C) osteoblasts become osteoclasts.
D) osteoclasts become osteocytes.

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Bone cells called ________ break down bone by secreting hydrochloric acid and enzymes that dissolve the matrix.


A) osteoprogenitor cells
B) osteoid cells
C) osteocytes
D) osteoclasts
E) osteoblasts

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When during human development does the process of ossification begin?


A) 12 weeks after birth
B) 12th-13th week of embryonic development
C) 8th-9th month of fetal development
D) 3-4 months of age
E) 10-25 years of age

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Bone is considered part of the skeletal system, but ligaments are not.

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The steps in the process of endochondral ossification are A: Ossification center forms in the diaphysis. B: Cartilage calcifies and a bone collar forms. C: Ossification centers form in the epiphyses. D: Bone replaces cartilage. E: Epiphyseal plates ossify. F: Cartilage model develops. The correct chronological order for these steps is


A) f. - b. - c. - d. - a. - e.
B) b. - c. - f. - a. - e. - d.
C) a. - c. - b. - d. - e. - f.
D) f. - b. - a. - c. - d. - e.
E) a. - e. - c. - d. - b. - f.

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Which is not correct about spongy bone?


A) Its spaces hold red bone marrow.
B) It is located deep to compact bone.
C) It forms diploe in the cranial bones.
D) It is composed of tubular units called osteons.
E) It is located in the epiphyses of long bones.

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Neither short nor flat bones contain a medullary cavity.

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Consider the classifications of bone, and examples of each. Which classification comprises bones used primarily for movement rather than protection?


A) Short bones
B) Long bones
C) Flat bones
D) Irregular bones
E) Regular bones

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Glucocorticoids increase bone ________; high levels of serotonin lead to ________ bone density.


A) formation; high
B) formation; low
C) loss; high
D) loss; low

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To trigger bone growth, growth hormone stimulates the


A) liver to produce somatomedin.
B) liver to produce calcitonin.
C) brain to produce serotonin.
D) parathyroid to produce parathyroid hormone.
E) thyroid to produce calcitriol.

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Where does hemopoiesis occur?


A) Epiphyseal line
B) Endosteum
C) Red bone marrow
D) Yellow bone marrow
E) Nutrient foramina

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Which affects osteoblast and osteoclast activity?


A) Gravity
B) Mechanical stress
C) Calcitonin and parathyroid hormone levels
D) Blood calcium level
E) All of the choices are correct.

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Within which zone of the epiphyseal plate do cartilage cells undergo mitosis?


A) The zone closest to the medullary cavity
B) The zone closest to the epiphysis
C) The second closest bone to the medullary cavity
D) The second closest zone to the epiphysis

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If a clinician were looking to harvest bone marrow that made blood cells, which bone of a donor would be sampled?


A) Distal head of femur
B) Os coxa
C) Phalanges
D) Distal humerus

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During the process of endochondral ossification, chondrocytes in the cartilage model die. Why does this occur?


A) Blood supply to the cartilage is cut off by the developing periosteum.
B) Canaliculi connecting adjacent chondrocyte lacunae fuse.
C) Nutrients cannot diffuse to the chondrocytes through the calcified matrix.
D) The developing bone collar secretes enzymes that destroy the chondrocytes.
E) Phagocytic osteoclasts in the new bone engulf and destroy the chondrocytes.

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The bones of the fingers and toes (phalanges) are categorized as _____ bones.


A) long
B) irregular
C) short
D) flat
E) sesamoid

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When bone forms by intramembranous ossification, the ossification centers are within


A) hyaline cartilage.
B) compact bone.
C) mesenchyme.
D) elastic cartilage.
E) spongy bone.

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