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A differential cell count is used to determine each of the following EXCEPT


A) the numbers of each type of white blood cell.
B) leukocytosis.
C) leukopenia.
D) the number of red blood cells.
E) the total number of white blood cells.

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Neutrophils with defective lysosomes are unable to


A) attach to microorganisms and other foreign material.
B) undergo chemotaxis.
C) migrate.
D) engulf microorganisms and other foreign material.
E) produce toxic oxygen products.

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All of the following are components of the inflammatory process EXCEPT


A) diapedesis.
B) chemotaxis.
C) release of histamines and prostaglandins.
D) antibody synthesis.
E) dilation of blood vessels.

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The alternative pathway for complement activation is initiated by


A) antigen-antibody reactions.
B) factors released from damaged tissues.
C) lipid- carbohydrate complexes and C3.
D) C5-C9.
E) factors released from phagocytes.

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Innate immunity


A) provides increased susceptibility to disease.
B) is slower than adaptive immunity in responding to pathogens.
C) involves a memory component.
D) involves T cells and B cells.
E) is nonspecific and present at birth.

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Describe the nonspecific antimicrobial effects of mucus, lysozyme, and low pH. For each of these substances, list where they are found in the body and how they function in fighting pathogens.

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Mucus, lysozyme, and low pH all play imp...

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All of the following are true regarding NK cells EXCEPT


A) they are a type of lymphocyte.
B) they release toxic substances that cause cell lysis or apoptosis.
C) they have the ability to kill infected body cells and some tumor cells.
D) they are found in tissues of the lymphatic system.
E) they destroy infected body cells by phagocytosis.

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The function of the "ciliary escalator" is to


A) remove microorganisms from the gastrointestinal tract.
B) propel inhaled dust and microorganisms toward the throat.
C) remove microorganisms from the upper respiratory tract.
D) remove microorganisms from the lower respiratory tract.
E) trap inhaled dust and microorganisms in mucous and propel it away from the lower respiratory tract.

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The inflammatory response can only be triggered by an infection.

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False

Digestion of microorganisms occurs in phagosomes.

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Which of the following statements is TRUE?


A) There are at least thirty complement proteins.
B) Complement activity is antigen- specific.
C) Complement increases after immunization.
D) Factors B, D, and P cause cytolysis.
E) All of the complement proteins are constantly active in serum.

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A

A child falls and suffers a deep cut on her leg. The cut went through her skin and she is bleeding. Which of the following defense mechanisms will participate in eliminating contaminating microbes?


A) normal skin flora
B) acidic skin secretions
C) lysozyme
D) mucociliary escalator
E) phagocytosis in the inflammatory response

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Which of the following statements about the classical pathway of complement activation is FALSE?


A) Cleaved fragments of some of the proteins act to increase inflammation.
B) The C1 protein complex is initiated by antigen-antibody complexes.
C) C3b causes opsonization.
D) C3 is not involved in the classical pathway.
E) C1 is the first protein activated in the classical pathway.

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After ingesting a pathogen, lysosomal enzymes produce all of the following EXCEPT


A) HOCl.
B) OHยท.
C) complement.
D) O2- .
E) H2O2.

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TLRs attach to all of the following EXCEPT


A) AMPs.
B) peptidoglycan.
C) LPS.
D) flagellin.
E) PAMPs.

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Which non- specific defense mechanism is mismatched with its associated body structure or body fluid?


A) cerumen and sebum - ear
B) lysozyme - tears and saliva
C) keratin and tightly packed cells - skin
D) mucociliary escalator - intestines
E) very acidic pH- stomach

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Aspirin alleviates pain, inflammation, and fever by inhibiting prostaglandins.

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True

All of the following pertain to fever EXCEPT that it


A) stimulates T lymphocyte activity.
B) intensifies the effect of antiviral interferons.
C) is caused by interleukin- 1 and TNF- alpha coming into contact with the hypothalamus.
D) can be initiated by specific types of pathogens.
E) accelerates microbial growth by increasing iron absorption from the digestive tract.

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All of the following are part of the mechanism of action of alpha and beta interferons EXCEPT


A) they disrupt stages of viral multiplication.
B) they initiate transcription.
C) they initiate manufacture of antiviral proteins.
D) they are effective for long periods.
E) they bind to the surface of uninfected cells.

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All of the following are affects of histamine EXCEPT


A) swelling.
B) fever.
C) redness.
D) pain.
E) vasodilation.

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