Question 1

Which of the following statements about protein-ligand binding is correct?

Accepted Answer

A)  The Ka is equal to the concentration of ligand when all of the binding sites are occupied.
B)  The Ka is independent of such conditions as salt concentration and pH.
C)  The larger the Ka (association constant) ,the weaker the affinity.
D)  The larger the Ka,the faster is the binding.
E)  The larger the Ka,the smaller the Kd (dissociation constant) .

Question 2

Patients with chronic hypoxia (low O2 levels) due to decreased lung function may adapt by increasing their circulating BPG levels.Predict which of the following will be true for such a patient.

Accepted Answer

A)  p50 for O2 will be decreased.
B)  p50 for O2 will be increased.
C)  The R-state of hemoglobin will be favored.
D)  O2 binding to hemoglobin will be hyperbolic.
E)  None of the above

Question 3

Explain briefly why the relative affinity of heme for oxygen and carbon monoxide is changed by the presence of the myoglobin protein.

Accepted Answer

The geometry of binding O₂ and CO to heme...

Question 4

Which of the following is not correct concerning 2,3-bisphosphoglycerate (BPG) ?

Accepted Answer

A)  It binds at a distance from the heme groups of hemoglobin.
B)  It binds with lower affinity to fetal hemoglobin than to adult hemoglobin.
C)  It increases the affinity of hemoglobin for oxygen.
D)  It is an allosteric modulator.
E)  It is normally found associated with the hemoglobin extracted from red blood cells.

Question 5

What is the chemical basis for the specificity of binding of an immunoglobin antibody to a particular antigen?

Accepted Answer

Specific binding results from ...

Exam 5: Protein Function

Patients with chronic hypoxia (low O₂ levels) due to decreased lung function may adapt by increasing their circulating BPG levels.Predict which of the following will be true for such a patient.

Correct Answer
verified

Explain briefly why the relative affinity of heme for oxygen and carbon monoxide is changed by the presence of the myoglobin protein.

Correct Answer
verified
The geometry of binding O₂ and CO to heme...
View Answer

Which of the following is not correct concerning 2,3-bisphosphoglycerate (BPG) ?

Correct Answer
verified

Which of the following statements about protein-ligand binding is correct?

Correct Answer
verified

What is the chemical basis for the specificity of binding of an immunoglobin antibody to a particular antigen?

Correct Answer
verified
Specific binding results from ...
View Answer

Exam 5: Protein Function

Patients with chronic hypoxia (low O2 levels) due to decreased lung function may adapt by increasing their circulating BPG levels.Predict which of the following will be true for such a patient.

Correct AnswerverifiedShow Answer

Explain briefly why the relative affinity of heme for oxygen and carbon monoxide is changed by the presence of the myoglobin protein.

Correct AnswerverifiedThe geometry of binding O2 and CO to heme...View AnswerShow Answer

Which of the following is not correct concerning 2,3-bisphosphoglycerate (BPG) ?

Correct AnswerverifiedShow Answer

Which of the following statements about protein-ligand binding is correct?

Correct AnswerverifiedShow Answer

What is the chemical basis for the specificity of binding of an immunoglobin antibody to a particular antigen?

Correct AnswerverifiedSpecific binding results from ...View AnswerShow Answer

Patients with chronic hypoxia (low O₂ levels) due to decreased lung function may adapt by increasing their circulating BPG levels.Predict which of the following will be true for such a patient.

Correct Answer
verified

Correct Answer
verified
The geometry of binding O₂ and CO to heme...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
Specific binding results from ...
View Answer