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Which of the following statements is always TRUE?


A) A mutation is harmful.
B) Mutations lead to changes in protein function.
C) Changes in DNA lead to changes in protein function.
D) A change in the DNA may change a protein's shape and function.
E) A change in DNA will lead to cancer.

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Programmed cell death is called


A) apoptosis.
B) endocytosis.
C) cytokinesis.
D) cytolysis.
E) mitosis.

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Amino acid sequences result from the process of


A) transcription.
B) translation.
C) replication.
D) regulation.
E) complementary base pairing.

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If you ran a pharmaceutical company,what would be the most effective series of steps for your company to discover new drugs from plants and bring them to market?


A) Identify likely drug sources,test chemicals on cultured cells,select the most effective chemical,convert chemical into a form for delivery into humans,do clinical trials,get FDA approval for drug sales,scale up drug supply.
B) Identify likely drug sources,select the most effective chemical,convert chemical into a form for delivery into humans,test chemicals on cultured cells,do clinical trials,get FDA approval for drug sales,scale up drug supply.
C) Identify likely drug sources,select the most effective chemical,test chemicals on cultured cells,convert chemical into a form for delivery into humans,do clinical trials,scale up drug supply,get FDA approval for drug sales.
D) Get FDA approval for drug sales,identify likely drug sources,test chemicals on cultured cells,select the most effective chemical,convert chemical into a form for delivery into humans,do clinical trials,scale up drug supply.
E) Get FDA approval for drug sales,identify likely drug sources,test chemicals on cultured cells,do clinical trials,select the most effective chemical,convert chemical into a form for delivery into humans,scale up drug supply.

Correct Answer

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Which of the following cannot lead to a mutation?


A) replacing thymine with uracil when making RNA
B) deleting a portion of a gene
C) replacing thymine with guanine when copying DNA
D) inserting three base pairs into a gene
E) inserting one base pair into a gene

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Which of the following will lead to a new,inheritable allele?


A) a mutation in a sperm cell
B) a mutation in an egg cell
C) a mutation in an embryo
D) a mutation in the brain
E) All of the above except D.

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Cell division in cancerous tumors


A) proceeds until apoptosis.
B) is regulated by the cell cycle.
C) progresses at a predicted rate.
D) is regulated by checkpoints.
E) accumulates DNA damage.

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An allele is


A) any section of DNA.
B) a gene.
C) a specific section of a chromosome.
D) an alternate version of a gene.
E) a pair of genes.

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Which of the following is MOST accurate?


A) Women with just one abnormal BRCA allele are less likely to develop skin cancer than women with no abnormal alleles.
B) Women with two abnormal BRCA alleles are less likely to develop skin cancer than women with no abnormal alleles.
C) Women with just one abnormal BRCA allele are more likely to develop cancer than women with no abnormal alleles.
D) Women with just one abnormal BRCA allele are more likely to develop ovarian cancer than women with two abnormal alleles.
E) Women with two abnormal BRCA alleles are less likely to develop breast cancer than women with no abnormal alleles.

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In addition to breast cancer,women with a mutation in one of their BRCA genes have an increased likelihood of developing which of the following other types of cancer?


A) liver
B) lung
C) ovarian
D) skin
E) bone

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Which of the following is NOT a known carcinogen?


A) ultraviolet light
B) alcohol
C) charred food
D) smoking
E) None of the above;all are known carcinogens

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If a mutation alters a protein,which of the following is NOT a likely outcome of the mutation?


A) The shape of the protein may be different.
B) The protein may function differently.
C) The protein may cause a disease or illness.
D) The protein may not function at all.
E) The protein may be repaired by enzymes.

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Somatic cells are


A) cancer cells.
B) cells that become tumors.
C) cells that become eggs.
D) cells that become sperm.
E) cells that do not become reproductive cells.

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Why do people with "inherited cancer" often develop cancer at a relatively young age?


A) Predisposition does not increase the chances that other risk factors will lead to the progression of cancer.
B) All inherited alleles that are associated with cancer cause childhood cancers.
C) Cancer cannot be truly inherited,but certain alleles weaken the normal control points that prevent cancer,and this causes cancer to appear earlier in life.
D) Younger people are exposed to more risk factors than older people.
E) all of these

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A mutation in one cancer-related gene is not enough to cause a cell to become cancerous.Why?


A) We have more than two copies of every gene.
B) Cell division is controlled by many proteins,not just one.
C) We have two copies of every gene.
D) Nearby cells will repair the mutation.
E) The cell has to divide more times to become cancerous.

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Which family history most strongly suggests a risk of inherited breast cancer due to BRCA1 mutations?


A) many female relatives who were diagnosed with breast cancer in their 70s
B) many relatives with skin cancer
C) many relatives diagnosed with skin cancer at an early age
D) many female relatives diagnosed with breast cancer at an early age
E) many female relatives with both early breast cancer and ovarian cancer

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What is the difference between mutagens and carcinogens?


A) All mutagens are carcinogens.
B) All carcinogens are mutagens.
C) Carcinogens are any substance that damages DNA and can lead to cancer.
D) B and C
E) None of the above;they are the same thing with different names.

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Why does cancer affect older individuals more frequently than younger people?


A) Older people have more genes than younger people,so the tendency for the genes to be mutated increases.
B) Cells become more fragile and die more rapidly as people age.
C) Older people tend to smoke,which is a carcinogen and causes cancer.
D) Older people have had more time to accumulate mutations from various sources.
E) Older DNA is more susceptible to mutation than younger DNA.

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There are several different alleles for flower color in carnations.One of them causes white flowers;a different allele of the same gene causes red flowers.This means that all of the following are true,EXCEPT


A) white carnations have different DNA sequences than red carnations.
B) white carnations and red carnations have somewhat different proteins.
C) a carnation plant could have one copy of the white allele and one copy of the red allele.
D) a carnation plant could have two copies of the white allele and two copies of the red allele.
E) All of the above.

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Why do people with inheritable high-risk mutations develop cancer at an earlier age?


A) People who have inherited high-risk mutations start life with at least one predisposing mutation,so they require fewer additional mutations.
B) People who have inherited high-risk mutations always have other environmental risk factors putting them at higher risk for developing cancer at a younger age.
C) People with inheritable high-risk mutations start expressing the mutated genes at a younger age.
D) The inherited mutations cause new mutations to occur more easily.
E) All the above.

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